N-acylation of ethanolamine using lipase: a chemoselective catalyst

The N-acylation of ethanolamine (2) with various fatty acids 1a–d and esters of fatty acids 1e–h using Candida antarctica B lipase (Novozym® 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, solid suppor...

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Bibliographic Details
Published in:Beilstein Journal of Organic Chemistry
Main Authors: Kidwai, Mazaahir, Poddar, Roona, Mothsra, Poonam
Format: Text
Language:English
Published: Beilstein-Institut 2009
Subjects:
Preliminary Communication
Antarc*
Antarctica
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686314
http://www.ncbi.nlm.nih.gov/pubmed/19478911
https://doi.org/10.3762/bjoc.5.10
Description
Summary:The N-acylation of ethanolamine (2) with various fatty acids 1a–d and esters of fatty acids 1e–h using Candida antarctica B lipase (Novozym® 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, solid supported and conventional methods were investigated and results were compared. There is a synergy between the enzyme catalysis and microwave irradiation.

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