Aquareovirus Effects Syncytiogenesis by Using a Novel Member of the FAST Protein Family Translated from a Noncanonical Translation Start Site▿

As nonenveloped viruses, the aquareoviruses and orthoreoviruses are unusual in their ability to induce cell-cell fusion and syncytium formation. While an extraordinary family of fusion-associated small transmembrane (FAST) proteins is responsible for orthoreovirus syncytiogenesis, the basis for aqua...

Full description

Bibliographic Details
Published in:Journal of Virology
Main Authors: Racine, Trina, Hurst, Tara, Barry, Chris, Shou, Jingyun, Kibenge, Frederick, Duncan, Roy
Format: Text
Language:English
Published: American Society for Microbiology (ASM) 2009
Subjects:
Virus-Cell Interactions
Atlantic salmon
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681948
http://www.ncbi.nlm.nih.gov/pubmed/19297495
https://doi.org/10.1128/JVI.00171-09
Description
Summary:As nonenveloped viruses, the aquareoviruses and orthoreoviruses are unusual in their ability to induce cell-cell fusion and syncytium formation. While an extraordinary family of fusion-associated small transmembrane (FAST) proteins is responsible for orthoreovirus syncytiogenesis, the basis for aquareovirus-induced syncytiogenesis is unknown. We now report that the S7 genome segment of an Atlantic salmon reovirus is polycistronic and uses a noncanonical CUG translation start codon to produce a 22-kDa integral membrane protein responsible for syncytiogenesis. The aquareovirus p22 protein represents a fourth distinct member of the FAST family with a unique repertoire and arrangement of structural motifs.

Similar Items