Molecular Characterization of Ofloxacin-Resistant Mycobacterium tuberculosis Strains from Russia▿ †

In this work, we studied the variation in the gyrA and gyrB genes in ofloxacin- and multidrug-resistant Mycobacterium tuberculosis strains circulating in northwest Russia. Comparison with spoligotyping data suggested that similar to the spread of multidrug-resistant tuberculosis, the spread of fluor...

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Bibliographic Details
Published in:Antimicrobial Agents and Chemotherapy
Main Authors: Mokrousov, Igor, Otten, Tatiana, Manicheva, Olga, Potapova, Yulia, Vishnevsky, Boris, Narvskaya, Olga, Rastogi, Nalin
Format: Text
Language:English
Published: American Society for Microbiology (ASM) 2008
Subjects:
Mechanisms of Resistance
Northwest Russia
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493099
http://www.ncbi.nlm.nih.gov/pubmed/18559646
https://doi.org/10.1128/AAC.00036-08
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Summary:In this work, we studied the variation in the gyrA and gyrB genes in ofloxacin- and multidrug-resistant Mycobacterium tuberculosis strains circulating in northwest Russia. Comparison with spoligotyping data suggested that similar to the spread of multidrug-resistant tuberculosis, the spread of fluoroquinolone-resistant tuberculosis in Russia may be due, at least partly, to the prevalence of the Beijing genotype in a local population of M. tuberculosis.

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