Intralobular Distribution of Vitamin A-Storing Lipid Droplets in Hepatic Stellate Cells with Special Reference to Polar Bear and Arctic Fox

We examined the liver of adult polar bears, arctic foxes, and rats by gold chloride staining, fluorescence microscopy for the detection of autofluorescence of vitamin A, hematoxylin-eosin staining, staining with Masson's trichrome, Ishii and Ishii's silver impregnation, and transmission el...

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Bibliographic Details
Published in:Comparative Hepatology
Main Authors: Higashi, Nobuyo, Imai, Katsuyuki, Sato, Mitsuru, Sato, Takeya, Kojima, Naosuke, Miura, Mitsutaka, Wold, Heidi L, Moskaug, Jan Øivind, Berg, Trond, Norum, Kaare R, Roos, Norbert, Wake, Kenjiro, Blomhoff, Rune, Senoo, Haruki
Format: Text
Language:English
Published: BioMed Central 2004
Subjects:
Proceedings
Arctic
Arctic Fox
polar bear
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409438
http://www.ncbi.nlm.nih.gov/pubmed/14960168
https://doi.org/10.1186/1476-5926-2-S1-S16
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Summary:We examined the liver of adult polar bears, arctic foxes, and rats by gold chloride staining, fluorescence microscopy for the detection of autofluorescence of vitamin A, hematoxylin-eosin staining, staining with Masson's trichrome, Ishii and Ishii's silver impregnation, and transmission electron microscopical morphometry. The liver lobules of the arctic animals showed a zonal gradient in the storage of vitamin A. The density (i.e., cell number per area) of hepatic stellate cells was essentially the same among the zones. These results indicate that the hepatic stellate cells of the polar bears and arctic foxes possess heterogeneity of vitamin A-storing capacity in their liver lobules.

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