Germline BRCA2 mutations in men with breast cancer.
Breast cancer in men is rare and is clearly due in some cases to an inherited predisposition. A total of 28 male breast cancer patients were tested for BRCA2 mutations; two frameshifts and one putative missense mutation were identified. One of the frameshifts was detected in the same position as a m...
Main Authors: | , , , |
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Format: | Text |
Language: | English |
Published: |
Nature Publishing Group
1997
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Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228180 http://www.ncbi.nlm.nih.gov/pubmed/9400938 |
Summary: | Breast cancer in men is rare and is clearly due in some cases to an inherited predisposition. A total of 28 male breast cancer patients were tested for BRCA2 mutations; two frameshifts and one putative missense mutation were identified. One of the frameshifts was detected in the same position as a mutation estimated to be responsible for 40% of all male breast cancer cases in Iceland. |
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