Germline BRCA2 mutations in men with breast cancer.

Breast cancer in men is rare and is clearly due in some cases to an inherited predisposition. A total of 28 male breast cancer patients were tested for BRCA2 mutations; two frameshifts and one putative missense mutation were identified. One of the frameshifts was detected in the same position as a m...

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Bibliographic Details
Main Authors: Mavraki, E., Gray, I. C., Bishop, D. T., Spurr, N. K.
Format: Text
Language:English
Published: Nature Publishing Group 1997
Subjects:
Research Article
Iceland
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228180
http://www.ncbi.nlm.nih.gov/pubmed/9400938
Description
Summary:Breast cancer in men is rare and is clearly due in some cases to an inherited predisposition. A total of 28 male breast cancer patients were tested for BRCA2 mutations; two frameshifts and one putative missense mutation were identified. One of the frameshifts was detected in the same position as a mutation estimated to be responsible for 40% of all male breast cancer cases in Iceland.

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