A subset of memory CD4+ helper T lymphocytes identified by expression of Pgp-1

The Pgp-1 glycoprotein (Ly-24 antigen) is acquired by mature murine T lymphocytes at the time of primary antigen stimulation Pgp-1 was previously shown to be a useful cell surface marker for distinguishing antigen-specific memory CD8+ T lymphocytes after immunization. Here we demonstrate that this o...

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Bibliographic Details
Format: Text
Language:English
Published: The Rockefeller University Press 1989
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Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189224
http://www.ncbi.nlm.nih.gov/pubmed/2564418
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Summary:The Pgp-1 glycoprotein (Ly-24 antigen) is acquired by mature murine T lymphocytes at the time of primary antigen stimulation Pgp-1 was previously shown to be a useful cell surface marker for distinguishing antigen-specific memory CD8+ T lymphocytes after immunization. Here we demonstrate that this observation extends to CD4+ T lymphocytes. Antigen-specific CD4+ T cells in mice immunized with sperm whale myoglobin or keyhole limpet hemocyanin were contained nearly exclusively in the minor Pgp-1+ subset.