Phosphodiesterase 4D and 5-Lipoxygenase Activating Protein in Ischemic Stroke
Risk for ischemic stroke is mediated by both environmental and genetic factors. Although several environmental exposures have been implicated, relatively little is known about the genetic basis of predisposition to this disease. Recent studies in Iceland identified risk polymorphisms in two putative...
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ftpubmed:oai:pubmedcentral.nih.gov:1774984 2023-05-15T16:49:25+02:00 Phosphodiesterase 4D and 5-Lipoxygenase Activating Protein in Ischemic Stroke Meschia, James F. Brott, Thomas G. Brown, Robert D. Crook, Richard Worrall, Bradford B. Kissela, Brett Brown, W. Mark Rich, Stephen S. Case, L. Douglas Evans, E. Whitney Hague, Stephen Singleton, Andrew Hardy, John 2005-09 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774984 http://www.ncbi.nlm.nih.gov/pubmed/16130105 https://doi.org/10.1002/ana.20585 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774984 http://www.ncbi.nlm.nih.gov/pubmed/16130105 http://dx.doi.org/10.1002/ana.20585 Article Text 2005 ftpubmed https://doi.org/10.1002/ana.20585 2013-08-31T16:32:17Z Risk for ischemic stroke is mediated by both environmental and genetic factors. Although several environmental exposures have been implicated, relatively little is known about the genetic basis of predisposition to this disease. Recent studies in Iceland identified risk polymorphisms in two putative candidate genes for ischemic stroke: phosphodiesterase 4D (PDE4D) and 5-lipoxygenase activating protein (ALOX5AP). A collection of North American sibling pairs concordant for ischemic stroke and two cohorts of prospectively ascertained North American ischemic stroke cases and control subjects were used for evaluation of PDE4D and ALOX5AP. Although no evidence supported linkage of ischemic stroke with either of the two candidate genes, single-nucleotide polymorphisms and haplotypic associations were observed between PDE4D and ischemic stroke. There was no evidence of association between variants of ALOX5AP and ischemic stroke. These data suggest that common variants in PDE4D may contribute to the genetic risk for ischemic stroke in multiple populations. Text Iceland PubMed Central (PMC) Annals of Neurology 58 3 351 361 |
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Article Meschia, James F. Brott, Thomas G. Brown, Robert D. Crook, Richard Worrall, Bradford B. Kissela, Brett Brown, W. Mark Rich, Stephen S. Case, L. Douglas Evans, E. Whitney Hague, Stephen Singleton, Andrew Hardy, John Phosphodiesterase 4D and 5-Lipoxygenase Activating Protein in Ischemic Stroke |
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Risk for ischemic stroke is mediated by both environmental and genetic factors. Although several environmental exposures have been implicated, relatively little is known about the genetic basis of predisposition to this disease. Recent studies in Iceland identified risk polymorphisms in two putative candidate genes for ischemic stroke: phosphodiesterase 4D (PDE4D) and 5-lipoxygenase activating protein (ALOX5AP). A collection of North American sibling pairs concordant for ischemic stroke and two cohorts of prospectively ascertained North American ischemic stroke cases and control subjects were used for evaluation of PDE4D and ALOX5AP. Although no evidence supported linkage of ischemic stroke with either of the two candidate genes, single-nucleotide polymorphisms and haplotypic associations were observed between PDE4D and ischemic stroke. There was no evidence of association between variants of ALOX5AP and ischemic stroke. These data suggest that common variants in PDE4D may contribute to the genetic risk for ischemic stroke in multiple populations. |
format |
Text |
author |
Meschia, James F. Brott, Thomas G. Brown, Robert D. Crook, Richard Worrall, Bradford B. Kissela, Brett Brown, W. Mark Rich, Stephen S. Case, L. Douglas Evans, E. Whitney Hague, Stephen Singleton, Andrew Hardy, John |
author_facet |
Meschia, James F. Brott, Thomas G. Brown, Robert D. Crook, Richard Worrall, Bradford B. Kissela, Brett Brown, W. Mark Rich, Stephen S. Case, L. Douglas Evans, E. Whitney Hague, Stephen Singleton, Andrew Hardy, John |
author_sort |
Meschia, James F. |
title |
Phosphodiesterase 4D and 5-Lipoxygenase Activating Protein in Ischemic Stroke |
title_short |
Phosphodiesterase 4D and 5-Lipoxygenase Activating Protein in Ischemic Stroke |
title_full |
Phosphodiesterase 4D and 5-Lipoxygenase Activating Protein in Ischemic Stroke |
title_fullStr |
Phosphodiesterase 4D and 5-Lipoxygenase Activating Protein in Ischemic Stroke |
title_full_unstemmed |
Phosphodiesterase 4D and 5-Lipoxygenase Activating Protein in Ischemic Stroke |
title_sort |
phosphodiesterase 4d and 5-lipoxygenase activating protein in ischemic stroke |
publishDate |
2005 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774984 http://www.ncbi.nlm.nih.gov/pubmed/16130105 https://doi.org/10.1002/ana.20585 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774984 http://www.ncbi.nlm.nih.gov/pubmed/16130105 http://dx.doi.org/10.1002/ana.20585 |
op_doi |
https://doi.org/10.1002/ana.20585 |
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Annals of Neurology |
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58 |
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3 |
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351 |
op_container_end_page |
361 |
_version_ |
1766039559341080576 |