Phosphodiesterase 4D and 5-Lipoxygenase Activating Protein in Ischemic Stroke

Risk for ischemic stroke is mediated by both environmental and genetic factors. Although several environmental exposures have been implicated, relatively little is known about the genetic basis of predisposition to this disease. Recent studies in Iceland identified risk polymorphisms in two putative...

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Bibliographic Details
Published in:Annals of Neurology
Main Authors: Meschia, James F., Brott, Thomas G., Brown, Robert D., Crook, Richard, Worrall, Bradford B., Kissela, Brett, Brown, W. Mark, Rich, Stephen S., Case, L. Douglas, Evans, E. Whitney, Hague, Stephen, Singleton, Andrew, Hardy, John
Format: Text
Language:English
Published: 2005
Subjects:
Article
Iceland
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774984
http://www.ncbi.nlm.nih.gov/pubmed/16130105
https://doi.org/10.1002/ana.20585
Description
Summary:Risk for ischemic stroke is mediated by both environmental and genetic factors. Although several environmental exposures have been implicated, relatively little is known about the genetic basis of predisposition to this disease. Recent studies in Iceland identified risk polymorphisms in two putative candidate genes for ischemic stroke: phosphodiesterase 4D (PDE4D) and 5-lipoxygenase activating protein (ALOX5AP). A collection of North American sibling pairs concordant for ischemic stroke and two cohorts of prospectively ascertained North American ischemic stroke cases and control subjects were used for evaluation of PDE4D and ALOX5AP. Although no evidence supported linkage of ischemic stroke with either of the two candidate genes, single-nucleotide polymorphisms and haplotypic associations were observed between PDE4D and ischemic stroke. There was no evidence of association between variants of ALOX5AP and ischemic stroke. These data suggest that common variants in PDE4D may contribute to the genetic risk for ischemic stroke in multiple populations.

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