The BARD1 Cys557Ser Variant and Breast Cancer Risk in Iceland

In a population-based cohort of 1090 Icelandic patients, a Cys557Ser missense variant of the BARD1 gene, which interacts with BRCA1, increased the risk of single and multiple primary breast cancers.

Bibliographic Details
Published in:	PLoS Medicine
Main Authors:	Stacey, Simon N, Sulem, Patrick, Johannsson, Oskar T, Helgason, Agnar, Gudmundsson, Julius, Kostic, Jelena P, Kristjansson, Kristleifur, Jonsdottir, Thora, Sigurdsson, Helgi, Hrafnkelsson, Jon, Johannsson, Jakob, Sveinsson, Thorarinn, Myrdal, Gardar, Grimsson, Hlynur Niels, Bergthorsson, Jon T, Amundadottir, Laufey T, Gulcher, Jeffrey R, Thorsteinsdottir, Unnur, Kong, Augustine, Stefansson, Kari
Format:	Text
Language:	English
Published:	Public Library of Science 2006
Subjects:	Research Article Iceland
Online Access:	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479388 http://www.ncbi.nlm.nih.gov/pubmed/16768547 https://doi.org/10.1371/journal.pmed.0030217

Description
Summary:	In a population-based cohort of 1090 Icelandic patients, a Cys557Ser missense variant of the BARD1 gene, which interacts with BRCA1, increased the risk of single and multiple primary breast cancers.