Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022

In 2021 and 2022, clade 2.3.4.4b H5Nx high pathogenicity avian influenza viruses were detected in one harbor seal and in one adult and three fox cubs in Denmark. The viruses were closely related to contemporary viruses found in Europe, and some had obtained amino acid substitutions related to mammal...

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Bibliographic Details
Published in:Influenza and Other Respiratory Viruses
Main Authors: Liang, Yuan, Hjulsager, Charlotte K., Jensen, Tim K., Hammer, Anne Sofie V., Ovesen, Maibritt T., Larsen, Lars E.
Format: Text
Language:English
Published: John Wiley and Sons Inc. 2023
Subjects:
Short Communications
harbor seal
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577164/
http://www.ncbi.nlm.nih.gov/pubmed/37850154
https://doi.org/10.1111/irv.13208
Description
Summary:In 2021 and 2022, clade 2.3.4.4b H5Nx high pathogenicity avian influenza viruses were detected in one harbor seal and in one adult and three fox cubs in Denmark. The viruses were closely related to contemporary viruses found in Europe, and some had obtained amino acid substitutions related to mammalian adaptation. Notably, the virus distribution appeared to have been different in the infected fox cubs, as one exclusively tested positive for the presence of HPAIV in the brain and the other two only in the lung. Collectively, these findings stress the need for increased disease surveillance of wild and farmed mammals.

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