Heterogeneity of pathological prion protein accumulation in the brain of moose (Alces alces) from Norway, Sweden and Finland with chronic wasting disease
Prion diseases are a group of neurodegenerative, transmissible, and fatal disorders that affect several animal species. They are characterized by the conformational conversion of the cellular prion protein (PrP(C)) into the pathological prion protein (PrP(Sc)). In 2016, chronic wasting disease (CWD)...
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BioMed Central
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492377/ http://www.ncbi.nlm.nih.gov/pubmed/37684668 https://doi.org/10.1186/s13567-023-01208-3 |
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ftpubmed:oai:pubmedcentral.nih.gov:10492377 2023-10-09T21:44:19+02:00 Heterogeneity of pathological prion protein accumulation in the brain of moose (Alces alces) from Norway, Sweden and Finland with chronic wasting disease Sola, Diego Tran, Linh Våge, Jørn Madslien, Knut Vuong, Tram T. Korpenfelt, Sirkka Liisa Ågren, Erik O. Averhed, Gustav Nöremark, Maria Sörén, Kaisa Isaksson, Mats Acín, Cristina Badiola, Juan José Gavier-Widén, Dolores Benestad, Sylvie L. 2023-09-08 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492377/ http://www.ncbi.nlm.nih.gov/pubmed/37684668 https://doi.org/10.1186/s13567-023-01208-3 en eng BioMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492377/ http://www.ncbi.nlm.nih.gov/pubmed/37684668 http://dx.doi.org/10.1186/s13567-023-01208-3 © L’Institut National de Recherche en Agriculture, Alimentation et Environnement (INRAE) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Vet Res Research Article Text 2023 ftpubmed https://doi.org/10.1186/s13567-023-01208-3 2023-09-17T00:44:56Z Prion diseases are a group of neurodegenerative, transmissible, and fatal disorders that affect several animal species. They are characterized by the conformational conversion of the cellular prion protein (PrP(C)) into the pathological prion protein (PrP(Sc)). In 2016, chronic wasting disease (CWD) gained great importance at European level due to the first disease detection in a wild reindeer (Rangifer tarandus) in Norway. The subsequent intensive CWD surveillance launched in cervids resulted in the detection of CWD in moose (Alces alces), with 11 cases in Norway, 3 in Finland and 4 in Sweden. These moose cases differ considerably from CWD cases in North American and reindeer in Norway, as PrP(Sc) was detectable in the brain but not in lymphoid tissues. These facts suggest the occurrence of a new type of CWD. Here, we show some immunohistochemical features that are clearly different from CWD cases in North American and Norwegian reindeer. Further, the different types of PrP(Sc) deposits found among moose demonstrate strong variations between the cases, supporting the postulation that these cases could carry multiple strains of CWD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13567-023-01208-3. Text Alces alces Rangifer tarandus PubMed Central (PMC) Norway Veterinary Research 54 1 |
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English |
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Research Article |
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Research Article Sola, Diego Tran, Linh Våge, Jørn Madslien, Knut Vuong, Tram T. Korpenfelt, Sirkka Liisa Ågren, Erik O. Averhed, Gustav Nöremark, Maria Sörén, Kaisa Isaksson, Mats Acín, Cristina Badiola, Juan José Gavier-Widén, Dolores Benestad, Sylvie L. Heterogeneity of pathological prion protein accumulation in the brain of moose (Alces alces) from Norway, Sweden and Finland with chronic wasting disease |
topic_facet |
Research Article |
description |
Prion diseases are a group of neurodegenerative, transmissible, and fatal disorders that affect several animal species. They are characterized by the conformational conversion of the cellular prion protein (PrP(C)) into the pathological prion protein (PrP(Sc)). In 2016, chronic wasting disease (CWD) gained great importance at European level due to the first disease detection in a wild reindeer (Rangifer tarandus) in Norway. The subsequent intensive CWD surveillance launched in cervids resulted in the detection of CWD in moose (Alces alces), with 11 cases in Norway, 3 in Finland and 4 in Sweden. These moose cases differ considerably from CWD cases in North American and reindeer in Norway, as PrP(Sc) was detectable in the brain but not in lymphoid tissues. These facts suggest the occurrence of a new type of CWD. Here, we show some immunohistochemical features that are clearly different from CWD cases in North American and Norwegian reindeer. Further, the different types of PrP(Sc) deposits found among moose demonstrate strong variations between the cases, supporting the postulation that these cases could carry multiple strains of CWD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13567-023-01208-3. |
format |
Text |
author |
Sola, Diego Tran, Linh Våge, Jørn Madslien, Knut Vuong, Tram T. Korpenfelt, Sirkka Liisa Ågren, Erik O. Averhed, Gustav Nöremark, Maria Sörén, Kaisa Isaksson, Mats Acín, Cristina Badiola, Juan José Gavier-Widén, Dolores Benestad, Sylvie L. |
author_facet |
Sola, Diego Tran, Linh Våge, Jørn Madslien, Knut Vuong, Tram T. Korpenfelt, Sirkka Liisa Ågren, Erik O. Averhed, Gustav Nöremark, Maria Sörén, Kaisa Isaksson, Mats Acín, Cristina Badiola, Juan José Gavier-Widén, Dolores Benestad, Sylvie L. |
author_sort |
Sola, Diego |
title |
Heterogeneity of pathological prion protein accumulation in the brain of moose (Alces alces) from Norway, Sweden and Finland with chronic wasting disease |
title_short |
Heterogeneity of pathological prion protein accumulation in the brain of moose (Alces alces) from Norway, Sweden and Finland with chronic wasting disease |
title_full |
Heterogeneity of pathological prion protein accumulation in the brain of moose (Alces alces) from Norway, Sweden and Finland with chronic wasting disease |
title_fullStr |
Heterogeneity of pathological prion protein accumulation in the brain of moose (Alces alces) from Norway, Sweden and Finland with chronic wasting disease |
title_full_unstemmed |
Heterogeneity of pathological prion protein accumulation in the brain of moose (Alces alces) from Norway, Sweden and Finland with chronic wasting disease |
title_sort |
heterogeneity of pathological prion protein accumulation in the brain of moose (alces alces) from norway, sweden and finland with chronic wasting disease |
publisher |
BioMed Central |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492377/ http://www.ncbi.nlm.nih.gov/pubmed/37684668 https://doi.org/10.1186/s13567-023-01208-3 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Alces alces Rangifer tarandus |
genre_facet |
Alces alces Rangifer tarandus |
op_source |
Vet Res |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492377/ http://www.ncbi.nlm.nih.gov/pubmed/37684668 http://dx.doi.org/10.1186/s13567-023-01208-3 |
op_rights |
© L’Institut National de Recherche en Agriculture, Alimentation et Environnement (INRAE) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
op_doi |
https://doi.org/10.1186/s13567-023-01208-3 |
container_title |
Veterinary Research |
container_volume |
54 |
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1 |
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1779309274539753472 |