Heterogeneity of pathological prion protein accumulation in the brain of moose (Alces alces) from Norway, Sweden and Finland with chronic wasting disease

Prion diseases are a group of neurodegenerative, transmissible, and fatal disorders that affect several animal species. They are characterized by the conformational conversion of the cellular prion protein (PrP(C)) into the pathological prion protein (PrP(Sc)). In 2016, chronic wasting disease (CWD)...

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Bibliographic Details
Published in:Veterinary Research
Main Authors: Sola, Diego, Tran, Linh, Våge, Jørn, Madslien, Knut, Vuong, Tram T., Korpenfelt, Sirkka Liisa, Ågren, Erik O., Averhed, Gustav, Nöremark, Maria, Sörén, Kaisa, Isaksson, Mats, Acín, Cristina, Badiola, Juan José, Gavier-Widén, Dolores, Benestad, Sylvie L.
Format: Text
Language:English
Published: BioMed Central 2023
Subjects:
Research Article
Norway
Alces alces
Rangifer tarandus
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10492377/
http://www.ncbi.nlm.nih.gov/pubmed/37684668
https://doi.org/10.1186/s13567-023-01208-3
Description
Summary:Prion diseases are a group of neurodegenerative, transmissible, and fatal disorders that affect several animal species. They are characterized by the conformational conversion of the cellular prion protein (PrP(C)) into the pathological prion protein (PrP(Sc)). In 2016, chronic wasting disease (CWD) gained great importance at European level due to the first disease detection in a wild reindeer (Rangifer tarandus) in Norway. The subsequent intensive CWD surveillance launched in cervids resulted in the detection of CWD in moose (Alces alces), with 11 cases in Norway, 3 in Finland and 4 in Sweden. These moose cases differ considerably from CWD cases in North American and reindeer in Norway, as PrP(Sc) was detectable in the brain but not in lymphoid tissues. These facts suggest the occurrence of a new type of CWD. Here, we show some immunohistochemical features that are clearly different from CWD cases in North American and Norwegian reindeer. Further, the different types of PrP(Sc) deposits found among moose demonstrate strong variations between the cases, supporting the postulation that these cases could carry multiple strains of CWD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13567-023-01208-3.

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