Keratinocytes drive the epithelial hyperplasia key to sea lice resistance in coho salmon.

Salmonid species have followed markedly divergent evolutionary trajectories in their interactions with sea lice. While sea lice parasitism poses significant economic, environmental, and animal welfare challenges for Atlantic salmon (Salmo salar) aquaculture, coho salmon (Oncorhynchus kisutch) exhibi...

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Bibliographic Details
Published in:BMC Biology
Main Authors: Salisbury, S J, Daniels, R Ruiz, Monaghan, S J, Bron, J E, Villamayor, P R, Gervais, O, Fast, M D, Sveen, L, Houston, R D, Robinson, N, Robledo, D
Format: Article in Journal/Newspaper
Language:English
Published: BioMed Central 2024
Subjects:
Aquaculture
Cell type
Disease
Immunity
Parasite
Salmon
Sea lice
Skin
Wound healing
snRNAseq
Atlantic salmon
Salmo salar
Online Access:https://doi.org/10.1186/s12915-024-01952-8
https://pubmed.ncbi.nlm.nih.gov/39075472
Description
Summary:Salmonid species have followed markedly divergent evolutionary trajectories in their interactions with sea lice. While sea lice parasitism poses significant economic, environmental, and animal welfare challenges for Atlantic salmon (Salmo salar) aquaculture, coho salmon (Oncorhynchus kisutch) exhibit near-complete resistance to sea lice, achieved through a potent epithelial hyperplasia response leading to rapid louse detachment. The molecular mechanisms underlying these divergent responses to sea lice are unknown.

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