Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes.

Modic changes (MC) are bone marrow lesions of vertebral bones, which can be detected with magnetic resonance imaging (MRI) adjacent to degenerated intervertebral discs. Defined by their appearance on T1 and T2 weighted images, there are three interconvertible types: MC1, MC2, and MC3. The inter-obse...

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Published in:JOR SPINE
Main Authors: Schulze, Friederike, Määttä, Juhani, Grad, Sybille, Heggli, Irina, Brunner, Florian, Farshad, Mazda, Distler, Oliver, Karppinen, Jaro, Lotz, Jeffrey, Dudli, Stefan
Format: Article in Journal/Newspaper
Language:English
Published: PubMed Central 2024
Subjects:
Modic changes
degenerative disc disease
low back pain
northern Finland birth cohort
proteomics
serum‐biomarker
Northern Finland
Online Access:https://doi.org/10.1002/jsp2.1337
https://pubmed.ncbi.nlm.nih.gov/39015135
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250394/
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spelling ftpubmed:39015135 2024-09-15T18:25:36+00:00 Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes. Schulze, Friederike Määttä, Juhani Grad, Sybille Heggli, Irina Brunner, Florian Farshad, Mazda Distler, Oliver Karppinen, Jaro Lotz, Jeffrey Dudli, Stefan 2024 Sep https://doi.org/10.1002/jsp2.1337 https://pubmed.ncbi.nlm.nih.gov/39015135 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250394/ eng eng PubMed Central https://doi.org/10.1002/jsp2.1337 https://pubmed.ncbi.nlm.nih.gov/39015135 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250394/ © 2024 The Author(s). JOR Spine published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society. JOR Spine ISSN:2572-1143 Volume:7 Issue:3 Modic changes degenerative disc disease low back pain northern Finland birth cohort proteomics serum‐biomarker Journal Article 2024 ftpubmed https://doi.org/10.1002/jsp2.1337 2024-07-18T16:03:00Z Modic changes (MC) are bone marrow lesions of vertebral bones, which can be detected with magnetic resonance imaging (MRI) adjacent to degenerated intervertebral discs. Defined by their appearance on T1 and T2 weighted images, there are three interconvertible types: MC1, MC2, and MC3. The inter-observer variability of the MRI diagnosis is high, therefore a diagnostic serum biomarker complementing the MRI to facilitate diagnosis and follow-up would be of great value. Article in Journal/Newspaper Northern Finland PubMed Central (PMC) JOR SPINE 7 3
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Modic changes
degenerative disc disease
low back pain
northern Finland birth cohort
proteomics
serum‐biomarker
spellingShingle Modic changes
degenerative disc disease
low back pain
northern Finland birth cohort
proteomics
serum‐biomarker
Schulze, Friederike
Määttä, Juhani
Grad, Sybille
Heggli, Irina
Brunner, Florian
Farshad, Mazda
Distler, Oliver
Karppinen, Jaro
Lotz, Jeffrey
Dudli, Stefan
Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes.
topic_facet Modic changes
degenerative disc disease
low back pain
northern Finland birth cohort
proteomics
serum‐biomarker
description Modic changes (MC) are bone marrow lesions of vertebral bones, which can be detected with magnetic resonance imaging (MRI) adjacent to degenerated intervertebral discs. Defined by their appearance on T1 and T2 weighted images, there are three interconvertible types: MC1, MC2, and MC3. The inter-observer variability of the MRI diagnosis is high, therefore a diagnostic serum biomarker complementing the MRI to facilitate diagnosis and follow-up would be of great value.
format Article in Journal/Newspaper
author Schulze, Friederike
Määttä, Juhani
Grad, Sybille
Heggli, Irina
Brunner, Florian
Farshad, Mazda
Distler, Oliver
Karppinen, Jaro
Lotz, Jeffrey
Dudli, Stefan
author_facet Schulze, Friederike
Määttä, Juhani
Grad, Sybille
Heggli, Irina
Brunner, Florian
Farshad, Mazda
Distler, Oliver
Karppinen, Jaro
Lotz, Jeffrey
Dudli, Stefan
author_sort Schulze, Friederike
title Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes.
title_short Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes.
title_full Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes.
title_fullStr Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes.
title_full_unstemmed Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes.
title_sort proteomic analysis of serum in a population-based cohort did not reveal a biomarker for modic changes.
publisher PubMed Central
publishDate 2024
url https://doi.org/10.1002/jsp2.1337
https://pubmed.ncbi.nlm.nih.gov/39015135
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250394/
genre Northern Finland
genre_facet Northern Finland
op_source JOR Spine
ISSN:2572-1143
Volume:7
Issue:3
op_relation https://doi.org/10.1002/jsp2.1337
https://pubmed.ncbi.nlm.nih.gov/39015135
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250394/
op_rights © 2024 The Author(s). JOR Spine published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society.
op_doi https://doi.org/10.1002/jsp2.1337
container_title JOR SPINE
container_volume 7
container_issue 3
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