Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes.

Modic changes (MC) are bone marrow lesions of vertebral bones, which can be detected with magnetic resonance imaging (MRI) adjacent to degenerated intervertebral discs. Defined by their appearance on T1 and T2 weighted images, there are three interconvertible types: MC1, MC2, and MC3. The inter-obse...

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Bibliographic Details
Published in:JOR SPINE
Main Authors: Schulze, Friederike, Määttä, Juhani, Grad, Sybille, Heggli, Irina, Brunner, Florian, Farshad, Mazda, Distler, Oliver, Karppinen, Jaro, Lotz, Jeffrey, Dudli, Stefan
Format: Article in Journal/Newspaper
Language:English
Published: PubMed Central 2024
Subjects:
Modic changes
degenerative disc disease
low back pain
northern Finland birth cohort
proteomics
serum‐biomarker
Northern Finland
Online Access:https://doi.org/10.1002/jsp2.1337
https://pubmed.ncbi.nlm.nih.gov/39015135
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250394/
Description
Summary:Modic changes (MC) are bone marrow lesions of vertebral bones, which can be detected with magnetic resonance imaging (MRI) adjacent to degenerated intervertebral discs. Defined by their appearance on T1 and T2 weighted images, there are three interconvertible types: MC1, MC2, and MC3. The inter-observer variability of the MRI diagnosis is high, therefore a diagnostic serum biomarker complementing the MRI to facilitate diagnosis and follow-up would be of great value.

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