Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes.
Modic changes (MC) are bone marrow lesions of vertebral bones, which can be detected with magnetic resonance imaging (MRI) adjacent to degenerated intervertebral discs. Defined by their appearance on T1 and T2 weighted images, there are three interconvertible types: MC1, MC2, and MC3. The inter-obse...
Published in: | JOR SPINE |
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Main Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
PubMed Central
2024
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Subjects: | |
Online Access: | https://doi.org/10.1002/jsp2.1337 https://pubmed.ncbi.nlm.nih.gov/39015135 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250394/ |
Summary: | Modic changes (MC) are bone marrow lesions of vertebral bones, which can be detected with magnetic resonance imaging (MRI) adjacent to degenerated intervertebral discs. Defined by their appearance on T1 and T2 weighted images, there are three interconvertible types: MC1, MC2, and MC3. The inter-observer variability of the MRI diagnosis is high, therefore a diagnostic serum biomarker complementing the MRI to facilitate diagnosis and follow-up would be of great value. |
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