A Systematic Review of the Prevalence of Germline BRCA mutations in North Asia Breast Cancer Patients.

The BRCA1/2 mutation status testing is the global standard of care for breast cancer patients with a family history of cancer. BRCA1/2 mutations are known to be ethno-specific. For some ethnic groups of the Northern Asia (Buryats, Yakuts, Altaians, Tuvans, Khakasses, etc.) the founder mutations in t...

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Bibliographic Details
Published in:Asian Pacific Journal of Cancer Prevention
Main Authors: Gervas, Polina, Aleksey, Molokov Yu, Nataliya, Babyshkina N, Kollantay, Olesya, Evgeny, Choynzonov L, Cherdyntseva, Nadezda V
Format: Article in Journal/Newspaper
Language:English
Published: Asian Pacific Organization for Cancer Prevention 2024
Subjects:
BRCA
Ethnic Groups
Indigenous Peoples
breast cancer
germline variant
Yakuts
Siberia
Online Access:https://doi.org/10.31557/APJCP.2024.25.6.1891
https://pubmed.ncbi.nlm.nih.gov/38918649
Description
Summary:The BRCA1/2 mutation status testing is the global standard of care for breast cancer patients with a family history of cancer. BRCA1/2 mutations are known to be ethno-specific. For some ethnic groups of the Northern Asia (Buryats, Yakuts, Altaians, Tuvans, Khakasses, etc.) the founder mutations in the BRCA1/2 genes have not been revealed. This systematic review was conducted to assess the prevalence of BRCA1/2 mutation in breast cancer patients inhabiting Eastern Europe and Northern Asia (or Siberia).

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