Analysis of admixed Greenlandic siblings shows that the mean genotypic values for metabolic phenotypes differ between Inuit and Europeans.

Disease prevalence and mean phenotype values differ between many populations, including Inuit and Europeans. Whether these differences are partly explained by genetic differences or solely due to differences in environmental exposures is still unknown, because estimates of the genetic contribution t...

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Bibliographic Details
Published in:Genome Medicine
Main Authors: Lin, Long, Andersen, Mette K, Stæger, Frederik Filip, Li, Zilong, Hanghøj, Kristian, Linneberg, Allan, Grarup, Niels, Jørgensen, Marit Eika, Hansen, Torben, Moltke, Ida, Albrechtsen, Anders
Format: Article in Journal/Newspaper
Language:English
Published: BioMed Central 2024
Subjects:
Admixture
Genotypic value
Greenlandic population
Sibling analysis
greenlandic
inuit
Online Access:https://doi.org/10.1186/s13073-024-01326-3
https://pubmed.ncbi.nlm.nih.gov/38778393
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11112775/
Description
Summary:Disease prevalence and mean phenotype values differ between many populations, including Inuit and Europeans. Whether these differences are partly explained by genetic differences or solely due to differences in environmental exposures is still unknown, because estimates of the genetic contribution to these means, which we will here refer to as mean genotypic values, are easily confounded, and because studies across genetically diverse populations are lacking.

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