Cystic fibrosis in Iceland and the high prevalence of the N1303K variant.

Cystic fibrosis (CF) is most common in populations of Northern European ancestry where the F508del variant predominates. In 2020, Iceland became a member of the European Cystic Fibrosis Society Patient Registry, and we launched an epidemiological study of CF in Iceland. The study aimed to determine...

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Bibliographic Details
Published in:Pediatric Pulmonology
Main Authors: Elidottir, Helga, Bjarnadottir, Selma R, Baldursson, Olafur, Jonsdottir, Brynja
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2024
Subjects:
CFTR gene variants
N1303K gene variant
cystic fibrosis epidemiology
cystic fibrosis incidence
cystic fibrosis prevalence
Iceland
Online Access:https://doi.org/10.1002/ppul.27019
https://pubmed.ncbi.nlm.nih.gov/38629430
Description
Summary:Cystic fibrosis (CF) is most common in populations of Northern European ancestry where the F508del variant predominates. In 2020, Iceland became a member of the European Cystic Fibrosis Society Patient Registry, and we launched an epidemiological study of CF in Iceland. The study aimed to determine the prevalence and the genetic variants present in the country. Furthermore, we aimed to describe the previous and the current situation regarding lung function, infections, complications, treatment, and follow-up to understand the strengths and weaknesses of CF care in Iceland.

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