Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study).

• Published in: Gut
• Main Authors: Kean, Iain Robert Louis, Clark, John A, Zhang, Zhenguang, Daubney, Esther, White, Deborah, Ferrando-Vivas, Paloma, Milla, Gema, Cuthbertson, Brian, Pappachan, John, Klein, Nigel, Mouncey, Paul, Rowan, Kathy, Myburgh, John, Gouliouris, Theodore, Baker, Stephen, Parkhill, Julian, Pathan, Nazima, Arctic Research Team
• Format: Article in Journal/Newspaper
• Language: English
• Published: HighWire 2024
• Subjects: ANTIBIOTIC THERAPY; DRUG RESISTANCE; Arctic
• Online Access: https://doi.org/10.1136/gutjnl-2023-330851; https://pubmed.ncbi.nlm.nih.gov/38253478

Selective decontamination of the digestive tract (SDD) is a well-studied but hotly contested medical intervention of enhanced infection control. Here, we aim to characterise the changes to the microbiome and antimicrobial resistance (AMR) gene profiles in critically ill children treated with SDD-enhanced infection control compared with conventional infection control.