Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study).

Selective decontamination of the digestive tract (SDD) is a well-studied but hotly contested medical intervention of enhanced infection control. Here, we aim to characterise the changes to the microbiome and antimicrobial resistance (AMR) gene profiles in critically ill children treated with SDD-enh...

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Bibliographic Details
Published in:Gut
Main Authors: Kean, Iain Robert Louis, Clark, John A, Zhang, Zhenguang, Daubney, Esther, White, Deborah, Ferrando-Vivas, Paloma, Milla, Gema, Cuthbertson, Brian, Pappachan, John, Klein, Nigel, Mouncey, Paul, Rowan, Kathy, Myburgh, John, Gouliouris, Theodore, Baker, Stephen, Parkhill, Julian, Pathan, Nazima, Arctic Research Team
Format: Article in Journal/Newspaper
Language:English
Published: HighWire 2024
Subjects:
ANTIBIOTIC THERAPY
DRUG RESISTANCE
Arctic
Online Access:https://doi.org/10.1136/gutjnl-2023-330851
https://pubmed.ncbi.nlm.nih.gov/38253478
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Summary:Selective decontamination of the digestive tract (SDD) is a well-studied but hotly contested medical intervention of enhanced infection control. Here, we aim to characterise the changes to the microbiome and antimicrobial resistance (AMR) gene profiles in critically ill children treated with SDD-enhanced infection control compared with conventional infection control.

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