Accelerated evolution at chaperone promoters among Antarctic notothenioid fishes.

Antarctic fishes of the Notothenioidei suborder constitutively upregulate multiple inducible chaperones, a highly derived adaptation that preserves proteostasis in extreme cold, and represent a system for studying the evolution of gene frontloading. We screened for Hsf1-binding sites, as Hsf1 is a m...

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Bibliographic Details
Published in:BMC Evolutionary Biology
Main Authors: Bogan, Samuel N, Place, Sean P
Format: Article in Journal/Newspaper
Language:English
Published: BioMed Central 2019
Subjects:
Comparative genomics
Environmental adaptation
Gene regulation
Heat shock proteins
Notothen
Promoters
cis-regulation
Antarctic
Antarc*
Online Access:https://doi.org/10.1186/s12862-019-1524-y
https://pubmed.ncbi.nlm.nih.gov/31694524
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836667/
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Summary:Antarctic fishes of the Notothenioidei suborder constitutively upregulate multiple inducible chaperones, a highly derived adaptation that preserves proteostasis in extreme cold, and represent a system for studying the evolution of gene frontloading. We screened for Hsf1-binding sites, as Hsf1 is a master transcription factor of the heat shock response, and highly-conserved non-coding elements within proximal promoters of chaperone genes across 10 Antarctic notothens, 2 subpolar notothens, and 17 perciform fishes. We employed phylogenetic models of molecular evolution to determine whether (i) changes in motifs associated with Hsf1-binding and/or (ii) relaxed purifying selection or exaptation at ancestral cis-regulatory elements coincided with the evolution of chaperone frontloading in Antarctic notothens.

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