A common variant associated with prostate cancer in European and African populations.

With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was assoc...

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Bibliographic Details
Published in:Nature Genetics
Main Authors: Amundadottir, Laufey T, Sulem, Patrick, Gudmundsson, Julius, Helgason, Agnar, Baker, Adam, Agnarsson, Bjarni A, Sigurdsson, Asgeir, Benediktsdottir, Kristrun R, Cazier, Jean-Baptiste, Sainz, Jesus, Jakobsdottir, Margret, Kostic, Jelena, Magnusdottir, Droplaug N, Ghosh, Shyamali, Agnarsson, Kari, Birgisdottir, Birgitta, Le Roux, Louise, Olafsdottir, Adalheidur, Blondal, Thorarinn, Andresdottir, Margret, Gretarsdottir, Olafia Svandis, Bergthorsson, Jon T, Gudbjartsson, Daniel, Gylfason, Arnaldur, Thorleifsson, Gudmar, Manolescu, Andrei, Kristjansson, Kristleifur, Geirsson, Gudmundur, Isaksson, Helgi, Douglas, Julie, Johansson, Jan-Erik, Bälter, Katarina, Wiklund, Fredrik, Montie, James E, Yu, Xiaoying, Suarez, Brian K, Ober, Carole, Cooney, Kathleen A, Gronberg, Henrik, Catalona, William J, Einarsson, Gudmundur V, Barkardottir, Rosa B, Gulcher, Jeffrey R, Kong, Augustine, Thorsteinsdottir, Unnur, Stefansson, Kari
Format: Article in Journal/Newspaper
Language:English
Published: Nature Publishing Group 2006
Subjects:
Iceland
Online Access:https://doi.org/10.1038/ng1808
https://pubmed.ncbi.nlm.nih.gov/16682969
Description
Summary:With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.

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