Nitrosporeusines A and B, Unprecedented Thioester-Bearing Alkaloids from the Arctic Streptomyces nitrosporeus

Chemical examination of an arctic actinomycete Streptomyces nitrosporeus resulted in the isolation of two new alkaloids named nitrosporeusines A (1) and B (2), an unprecedented skeleton containing benzenecarbothioc cyclopenta[c]pyrrole-1,3-dione. Their structures were determined through extensive sp...

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Bibliographic Details
Published in:Organic Letters
Main Authors: Yang, Aigang, Si, Longlong, Shi, Zhenping, Tian, Li, Liu, Dong, Zhou, Demin, Proksch, Peter, Lin, Wenhan
Other Authors: Tian, L (reprint author), Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China., Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China., SOA, Inst Oceannog 1, Qingdao 266061, Peoples R China., Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany.
Format: Journal/Newspaper
Language:English
Published: organic letters 2013
Subjects:
CELL PROTECTING ACTIVITY
BENZASTATIN-C
INHIBITOR
Arctic
Online Access:https://hdl.handle.net/20.500.11897/323020
https://doi.org/10.1021/ol4026809
Description
Summary:Chemical examination of an arctic actinomycete Streptomyces nitrosporeus resulted in the isolation of two new alkaloids named nitrosporeusines A (1) and B (2), an unprecedented skeleton containing benzenecarbothioc cyclopenta[c]pyrrole-1,3-dione. Their structures were determined through extensive spectroscopic analyses in association with X-ray single crystal diffraction. Both 1 and 2 exhibited inhibitory activities against the H1N1 virus in MDCK cells. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000326121700056&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 Chemistry, Organic SCI(E) PubMed 6 ARTICLE 20 5366-5369 15

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