Congener-specific tissue distribution and hepatic sequestration of PCDD/Fs in wild herring gulls from Bohai Bay, North China: Comparison to coplanar PCBs

Tissue distribution is an important property of pharmacokinetic behaviors of dioxins to provide information for risk assessment to wild avian species. In this study, concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and coplanar polychlorinated biphe...

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Bibliographic Details
Published in:Environmental Science & Technology
Main Authors: Wan, Y, Hu, JY, An, W, Zhang, ZB, An, LH, Hattori, T, Itoh, M, Masunaga, S
Other Authors: Hu, JY (reprint author), Peking Univ, Coll Environm Sci, Beijing 100871, Peoples R China., Peking Univ, Coll Environm Sci, Beijing 100871, Peoples R China., Metocean Environm Inc, Res Ctr Environm Risk, Inst Environm Ecol, Shizuoka 4210212, Japan., Yokohama Natl Univ, Grad Sch Environm & Informat Sci, Hodogaya Ku, Yokohama, Kanagawa 2408501, Japan.
Format: Journal/Newspaper
Language:English
Published: environmental science technology 2006
Subjects:
DIBENZO-P-DIOXINS
POLYCHLORINATED-BIPHENYLS PCBS
EQUIVALENCY FACTORS TEFS
PARTITION-COEFFICIENTS
PHOCOENA-PHOCOENA
LIPID-COMPOSITION
INCLUDING HUMANS
MALE-RATS
PCDFS
BIOACCUMULATION
Phocoena phocoena
Online Access:https://hdl.handle.net/20.500.11897/198953
https://doi.org/10.1021/es052249s
Description
Summary:Tissue distribution is an important property of pharmacokinetic behaviors of dioxins to provide information for risk assessment to wild avian species. In this study, concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and coplanar polychlorinated biphenyls (coplanar PCBs) were determined in muscle, liver, spleen, kidney, brain, and adipose of wild herring gulls collected from Bohai Bay, North China. Tissue distribution results showed preferential accumulation of PCDD/Fs in liver and of co-PCBs in adipose. The congener patterns of coplanar PCBs were constant in different tissues, but the congener patterns for PCDD/F were tissue specific. The liver/adipose concentration ratios for PCDD/Fs were found to increase statistically significantly with log K-ow, providing the quantitative relationship of structure-activity for hepatic sequestration of PCDD/Fs for the first time. Furthermore, this relationship was compared with those developed on the basis of previous results reported in the literature showing that the wild herring gulls in Bohai Bay are still in the exposure period. Engineering, Environmental Environmental Sciences SCI(E) EI PubMed 12 ARTICLE 5 1462-1468 40

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