Asperelines A-F, Peptaibols from the Marine-Derived Fungus Trichoderma asperellum
Fermentation of the marine-derived fungus Trichoderma asperellum, collected from the sediment of the Antarctic Penguin Island, resulted in the isolation of six new peptaibols named asperelines A-F (1-6), which are characterized by an acetylated N-terminus and a C-terminus containing an uncommon prol...
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Online Access: | https://hdl.handle.net/20.500.11897/156825 https://doi.org/10.1021/np900190w |
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ftpekinguniv:oai:localhost:20.500.11897/156825 2023-05-15T13:43:54+02:00 Asperelines A-F, Peptaibols from the Marine-Derived Fungus Trichoderma asperellum Ren, Jinwei Xue, Chunmei Tian, Li Xu, Minjuan Chen, Jian Deng, Zhiwei Proksch, Peter Lin, Wenhan Lin, WH (reprint author), Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China. Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China. Qingdao Univ Sci & Technol, Dept Biol, Qingdao 266042, Peoples R China. Beijing Normal Univ, Analyt & Testing Ctr, Beijing 100875, Peoples R China. Univ Dusseldorf, Inst Pharmazeut Biol, D-40225 Dusseldorf, Germany. Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Coll Chem, Wuhan 430079, Peoples R China. 2009 https://hdl.handle.net/20.500.11897/156825 https://doi.org/10.1021/np900190w en eng journal of natural products JOURNAL OF NATURAL PRODUCTS.2009,72,(6),1036-1044. 670305 0163-3864 http://hdl.handle.net/20.500.11897/156825 doi:10.1021/np900190w 19514743 WOS:000267432600010 SCI PubMed ANTIFUNGAL PEPTAIBOL ANTIBIOTICS CELLS PEPTAIBIOMICS ELUCIDATION VIRIDE Journal 2009 ftpekinguniv https://doi.org/20.500.11897/156825 https://doi.org/10.1021/np900190w 2021-08-01T08:03:32Z Fermentation of the marine-derived fungus Trichoderma asperellum, collected from the sediment of the Antarctic Penguin Island, resulted in the isolation of six new peptaibols named asperelines A-F (1-6), which are characterized by an acetylated N-terminus and a C-terminus containing an uncommon prolinol residue. Structures were determined by extensive 1D and 2D NMR ((1)H-(1)H COSY, HMQC, HMBC, NOESY) spectroscopic data analysis combined with ESIMS/MS fragmentation. The absolute configurations of the amino acid residues possessing a chiral alpha-carbon and of the prolinol residue were determined to be L and S, respectively, using a new method of (1)H NMR spectroscopic comparison of complexes formed between the chiral reagent Ru(D(4)-Por*)CO and amino acids derived from the peptaibols with those formed with reference standards. Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy SCI(E) PubMed 18 ARTICLE 6 1036-1044 72 Journal/Newspaper Antarc* Antarctic Penguin Island Peking University Institutional Repository (PKU IR) Antarctic Penguin Island ENVELOPE(-57.926,-57.926,-62.102,-62.102) The Antarctic Journal of Natural Products 72 6 1036 1044 |
institution |
Open Polar |
collection |
Peking University Institutional Repository (PKU IR) |
op_collection_id |
ftpekinguniv |
language |
English |
topic |
ANTIFUNGAL PEPTAIBOL ANTIBIOTICS CELLS PEPTAIBIOMICS ELUCIDATION VIRIDE |
spellingShingle |
ANTIFUNGAL PEPTAIBOL ANTIBIOTICS CELLS PEPTAIBIOMICS ELUCIDATION VIRIDE Ren, Jinwei Xue, Chunmei Tian, Li Xu, Minjuan Chen, Jian Deng, Zhiwei Proksch, Peter Lin, Wenhan Asperelines A-F, Peptaibols from the Marine-Derived Fungus Trichoderma asperellum |
topic_facet |
ANTIFUNGAL PEPTAIBOL ANTIBIOTICS CELLS PEPTAIBIOMICS ELUCIDATION VIRIDE |
description |
Fermentation of the marine-derived fungus Trichoderma asperellum, collected from the sediment of the Antarctic Penguin Island, resulted in the isolation of six new peptaibols named asperelines A-F (1-6), which are characterized by an acetylated N-terminus and a C-terminus containing an uncommon prolinol residue. Structures were determined by extensive 1D and 2D NMR ((1)H-(1)H COSY, HMQC, HMBC, NOESY) spectroscopic data analysis combined with ESIMS/MS fragmentation. The absolute configurations of the amino acid residues possessing a chiral alpha-carbon and of the prolinol residue were determined to be L and S, respectively, using a new method of (1)H NMR spectroscopic comparison of complexes formed between the chiral reagent Ru(D(4)-Por*)CO and amino acids derived from the peptaibols with those formed with reference standards. Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy SCI(E) PubMed 18 ARTICLE 6 1036-1044 72 |
author2 |
Lin, WH (reprint author), Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China. Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China. Qingdao Univ Sci & Technol, Dept Biol, Qingdao 266042, Peoples R China. Beijing Normal Univ, Analyt & Testing Ctr, Beijing 100875, Peoples R China. Univ Dusseldorf, Inst Pharmazeut Biol, D-40225 Dusseldorf, Germany. Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Coll Chem, Wuhan 430079, Peoples R China. |
format |
Journal/Newspaper |
author |
Ren, Jinwei Xue, Chunmei Tian, Li Xu, Minjuan Chen, Jian Deng, Zhiwei Proksch, Peter Lin, Wenhan |
author_facet |
Ren, Jinwei Xue, Chunmei Tian, Li Xu, Minjuan Chen, Jian Deng, Zhiwei Proksch, Peter Lin, Wenhan |
author_sort |
Ren, Jinwei |
title |
Asperelines A-F, Peptaibols from the Marine-Derived Fungus Trichoderma asperellum |
title_short |
Asperelines A-F, Peptaibols from the Marine-Derived Fungus Trichoderma asperellum |
title_full |
Asperelines A-F, Peptaibols from the Marine-Derived Fungus Trichoderma asperellum |
title_fullStr |
Asperelines A-F, Peptaibols from the Marine-Derived Fungus Trichoderma asperellum |
title_full_unstemmed |
Asperelines A-F, Peptaibols from the Marine-Derived Fungus Trichoderma asperellum |
title_sort |
asperelines a-f, peptaibols from the marine-derived fungus trichoderma asperellum |
publisher |
journal of natural products |
publishDate |
2009 |
url |
https://hdl.handle.net/20.500.11897/156825 https://doi.org/10.1021/np900190w |
long_lat |
ENVELOPE(-57.926,-57.926,-62.102,-62.102) |
geographic |
Antarctic Penguin Island The Antarctic |
geographic_facet |
Antarctic Penguin Island The Antarctic |
genre |
Antarc* Antarctic Penguin Island |
genre_facet |
Antarc* Antarctic Penguin Island |
op_source |
SCI PubMed |
op_relation |
JOURNAL OF NATURAL PRODUCTS.2009,72,(6),1036-1044. 670305 0163-3864 http://hdl.handle.net/20.500.11897/156825 doi:10.1021/np900190w 19514743 WOS:000267432600010 |
op_doi |
https://doi.org/20.500.11897/156825 https://doi.org/10.1021/np900190w |
container_title |
Journal of Natural Products |
container_volume |
72 |
container_issue |
6 |
container_start_page |
1036 |
op_container_end_page |
1044 |
_version_ |
1766194846581653504 |