Asperelines A-F, Peptaibols from the Marine-Derived Fungus Trichoderma asperellum
Fermentation of the marine-derived fungus Trichoderma asperellum, collected from the sediment of the Antarctic Penguin Island, resulted in the isolation of six new peptaibols named asperelines A-F (1-6), which are characterized by an acetylated N-terminus and a C-terminus containing an uncommon prol...
Published in: | Journal of Natural Products |
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Main Authors: | , , , , , , , |
Other Authors: | , , , , , |
Format: | Journal/Newspaper |
Language: | English |
Published: |
journal of natural products
2009
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Subjects: | |
Online Access: | https://hdl.handle.net/20.500.11897/156825 https://doi.org/10.1021/np900190w |
Summary: | Fermentation of the marine-derived fungus Trichoderma asperellum, collected from the sediment of the Antarctic Penguin Island, resulted in the isolation of six new peptaibols named asperelines A-F (1-6), which are characterized by an acetylated N-terminus and a C-terminus containing an uncommon prolinol residue. Structures were determined by extensive 1D and 2D NMR ((1)H-(1)H COSY, HMQC, HMBC, NOESY) spectroscopic data analysis combined with ESIMS/MS fragmentation. The absolute configurations of the amino acid residues possessing a chiral alpha-carbon and of the prolinol residue were determined to be L and S, respectively, using a new method of (1)H NMR spectroscopic comparison of complexes formed between the chiral reagent Ru(D(4)-Por*)CO and amino acids derived from the peptaibols with those formed with reference standards. Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy SCI(E) PubMed 18 ARTICLE 6 1036-1044 72 |
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