Seawater carbonate chemistry and drug concentrations in tissues, bioconcentration factor and enzymatic activity of Ruditapes philippinarum

• Main Authors: Almeida, Angela, Calisto, Vania, Esteves, Valdemar I, Schneider, Rudolf J, Soares, Amadeu M V M, Freitas, Rosa
• Format: Dataset
• Language: English
• Published: PANGAEA 2022
• Subjects: Alkalinity; total; standard deviation; Animalia; Aragonite saturation state; Benthic animals; Benthos; Bicarbonate ion; Bioconcentration factor; Bottles or small containers/Aquaria (<20 L); Brackish waters; Calcite saturation state; Calculated using CO2SYS; Calculated using seacarb after Nisumaa et al. (2010); Carbon; inorganic; dissolved; Carbonate ion; Carbonate system computation flag; Carbon dioxide; Catalase activity; per fresh mass; Drug concentration per fresh mass; Electron transport system activity of oyxgen; Energy transport system activity; Fugacity of carbon dioxide (water) at sea surface temperature (wet air); Glutathione reduced/Glutathione oxidized; ratio; Glutathione S-transferase activity; Ocean acidification
• Online Access: https://doi.pangaea.de/10.1594/PANGAEA.944572; https://doi.org/10.1594/PANGAEA.944572

In coastal systems, organisms are exposed to a multitude of stressors whose interactions and effects are poorly studied. Pharmaceutical drugs and Climate Change consequences, such as reduced pH, are examples of stressors affecting marine organisms, as bivalves. Although a vast literature is available for the effects of these stressors when acting individually, very limited information exists on the impacts that the combination of both can have on marine bivalves. For this reason, this study aimed to evaluate the impacts of a simulated ocean acidification scenario (control pH, 8.0; reduced pH, pH 7.6) on the effects of the antiepileptic carbamazepine (CBZ, 1 μg/L) and the antihistamine cetirizine (CTZ, 0.6 μg/L), when acting individually and combined (CBZ + CTZ), on the edible clam Ruditapes philippinarum. After 28 days of exposure, drug concentrations, bioconcentration factors and biochemical parameters related to the clam's metabolic capacity and oxidative stress were evaluated. The results showed that R. philippinarum clams responded differently to pharmaceutical drugs depending on the pH tested, influencing both bioconcentration and biological responses. In general, drug combined treatments showed fewer impacts than drugs acting alone, and acidification seemed to activate at a higher extension the elimination processes that were not activated under control pH. Also, reduced pH per se exerted negative impacts (e.g., cellular damage) on R. philippinarum and the combination with pharmaceutical drugs did not enhance the toxicity.