(Table 1) Polychlorinated biphenyl (PCB) and PCB metabolite concentrations in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea

Polychlorinated biphenyls (PCBs) may induce activity of hepatic enzymes, mainly Phase I monooxygenases and conjugating Phase II enzymes, that catalyze the metabolism of PCBs leading to formation of metabolites and to potential adverse health effects. The present study investigates the concentration...

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Bibliographic Details
Main Authors: Routti, Heli, Letcher, Robert J, Arukwe, Augustine, van Bavel, Bert, Yoccoz, Nigel G, Chu, Shaogang, Gabrielsen, Geir W
Format: Dataset
Language:English
Published: PANGAEA 2008
Subjects:
Age
relative
number of years
standard deviation
Area/locality
Baltic Sea
BalticSea_Bothnia
Biological sample
BIOS
Event label
Female
Hydroxy-polychlorinated biphenyl
International Polar Year (2007-2008)
IPY
Lipids
Male
Methyl sulfone polychlorinated biphenyl
MULT
Multiple investigations
Polychlorinated biphenyl
Sample amount
subset
Sample type
Sampling date
Species
common name
Svalbard
International Polar Year
Phoca hispida
ringed seal
Online Access:https://doi.pangaea.de/10.1594/PANGAEA.819407
https://doi.org/10.1594/PANGAEA.819407
Description
Summary:Polychlorinated biphenyls (PCBs) may induce activity of hepatic enzymes, mainly Phase I monooxygenases and conjugating Phase II enzymes, that catalyze the metabolism of PCBs leading to formation of metabolites and to potential adverse health effects. The present study investigates the concentration and pattern of PCBs, the induction of hepatic phase I and II enzymes, and the formation of hydroxy (OH) and methylsulfonyl (CH3SO2=MeSO2) PCB metabolites in two ringed seal (Phoca hispida) populations, which are contrasted by the degree of contamination exposure, that is, highly contaminated Baltic Sea (n = 31) and less contaminated Svalbard (n = 21). Phase I enzymes were measured as ethoxyresorufin-O-deethylation (EROD), benzyloxyresorufin-O-dealkylation (BROD), methoxyresorufin-O-demethylation (MROD), and pentoxyresorufin-O-dealkylation (PROD) activities, and phase II enzymes were measured as uridine diphosphophate glucuronosyl transferase (UDPGT) and glutathione-S-transferase (GST). Geographical comparison, multivariate, and correlation analysis indicated that sum-PCB had a positive impact on Phase I enzyme and GST activities leading to biotransformation of group III (vicinal ortho-meta-H atoms and <=1 ortho-chlorine (Cl)) and IV PCBs (vicinal meta-para-H atoms and <=2 ortho-Cl). The potential precursors for the main OH-PCBs detected in plasma in the Baltic seals were group III PCBs. MeSO2-PCBs detected in liver were mainly products of group IV PCB metabolism. Both CYP1A- and CYP2B-like enzymes are suggested to be involved in the PCB biotransformation in ringed seals.

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