Detection and quantitation of benzo(a)pyrene-DNA adducts in brain and liver tissues of Beluga whales (Delphinapterus leucas) from the St. Lawrence and Mackenzie Estuaries

It should be noted that there are few analytical techniques available for the detection and quantitation of chemical adducts in the DNA of living organisms. The reasons for this are: the analytical technique often has to accommodate the unique chemical and/or physical properties of the individual ch...

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Bibliographic Details
Main Author: Shugart, L.R.
Language:unknown
Published: 2008
Subjects:
63 RADIATION
THERMAL
AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZOPYRENE
TOXICITY
DNA ADDUCTS
BIOASSAY
BIOLOGICAL PATHWAYS
CETACEANS
GENE MUTATIONS
GENES
ADDUCTS
ANIMALS
AQUATIC ORGANISMS
AROMATICS
CONDENSED AROMATICS
HYDROCARBONS
MAMMALS
MUTATIONS
ORGANIC COMPOUNDS
VERTEBRATES
Beluga
Beluga*
Delphinapterus leucas
Online Access:http://www.osti.gov/servlets/purl/6861495
https://www.osti.gov/biblio/6861495
Description
Summary:It should be noted that there are few analytical techniques available for the detection and quantitation of chemical adducts in the DNA of living organisms. The reasons for this are: the analytical technique often has to accommodate the unique chemical and/or physical properties of the individual chemical or its metabolite; the percentage of total chemical that becomes most of the parent compound is usually detoxified and excreted; not all adducts that form between the genotoxic agent and DNA are stable or are involved in the development of subsequent deleterious events in the organism; and the amount of DNA available for analysis is often quite limited. 16 refs., 1 tab.

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