Genetic and physiological factors affecting repair and mutagenesis in yeast

• Main Author: Lemontt, J F
• Language: unknown
• Published: 2014
• Subjects: 63 RADIATION; THERMAL; AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; BIOLOGICAL PATHWAYS; GENETIC VARIABILITY; BIOLOGICAL REPAIR; DNA; DNA REPLICATION; GENE RECOMBINATION; MUTAGENESIS; COMPARATIVE EVALUATIONS; MUTATIONS; RADIOINDUCTION; SACCHAROMYCES CEREVISIAE; GENETIC RADIATION EFFECTS; DATA COMPILATION; EMS; GUANIDINES; HYDRAZINE; IRRADIATION; ISOLATED VALUES; METHYL METHANESULFONATE; MUTAGENS; NITROSO COMPOUNDS; NITROUS ACID; ULTRAVIOLET RADIATION; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; BIOLOGICAL VARIABILITY; CARBONIC ACID DERIVATIVES; DATA; DATA FORMS; ELECTROMAGNETIC RADIATION; ESTERS; FUNGI; GENETIC EFFECTS; HYDROGEN COMPOUNDS; INFORMATION; INORGANIC ACIDS; MICROORGANISMS; NITROGEN COMPOUNDS; NUCLEIC ACID REPLICATION; NUCLEIC ACIDS; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PLANTS; Carbonic acid
• Online Access: http://www.osti.gov/servlets/purl/6184830; https://www.osti.gov/biblio/6184830; https://doi.org/10.2172/6184830

Current views of DNA repair and mutagenesis in the yeast Saccharomyces cerevisiae are discussed in the light of recent data, and with emphasis on the isolation and characterization of genetically well-defined mutations that affect DNA metabolism in general (including replication and recombination). Various pathways of repair are described particularly in relation to their involvement in mutagenic mechanisms. In addition to genetic control, certain physiological factors such as cell age, DNA replication, and the regulatory state of the mating-type locus, are shown to also play a role in repair and mutagenesis.