Genetic and physiological factors affecting repair and mutagenesis in yeast

• Main Author: Lemontt, J F
• Language: unknown
• Published: 2014
• Subjects: 63 RADIATION; THERMAL; AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; BIOLOGICAL REPAIR; BIOLOGICAL PATHWAYS; DNA; MUTAGENESIS; AGE DEPENDENCE; GENETIC CONTROL; MUTATIONS; SACCHAROMYCES CEREVISIAE; CARBONIC ACID DERIVATIVES; DNA REPLICATION; EMS; EXPERIMENTAL DATA; GAMMA RADIATION; GENE RECOMBINATION; HYDRAZINE; ISOLATED VALUES; METHYL METHANESULFONATE; NITROSO COMPOUNDS; NITROUS ACID; ULTRAVIOLET RADIATION; X RADIATION; BIOLOGICAL RECOVERY; DATA; DATA FORMS; ELECTROMAGNETIC RADIATION; ESTERS; FUNGI; HYDROGEN COMPOUNDS; INFORMATION; INORGANIC ACIDS; IONIZING RADIATIONS; MICROORGANISMS; MUTAGENS; NITROGEN COMPOUNDS; NUCLEIC ACID REPLICATION; NUCLEIC ACIDS; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PEST CONTROL; PLANTS; RADIATIONS; RECOVERY; REPAIR; SACCHAROMYCES; Carbonic acid
• Online Access: http://www.osti.gov/servlets/purl/5875959; https://www.osti.gov/biblio/5875959

Current views of DNA repair and mutagenesis in the yeast Saccharomyces cerevisiae are discussed in the light of recent data and with emphasis on the isolation and characterization of genetically well-defined mutations that affect DNA metabolism in general (including replication and recombination). Various pathways of repair are described, particularly in relation to their imvolvement in mutagenic mechanisms. In addition to genetic control, certain physiological factors such as cell age, DNA replication, and the regulatory state of the mating-type locus are shown to also play a role in repair and mutagenesis.