The Lactate Dehydrogenase of the Icefish Heart: Biochemical Adaptations to Hypoxia Tolerance

peer reviewed Cardiac lactate dehydrogenase from the hemoglobin- and myoglobin-free antarctic icefish has been purified by affinity chromatography. Structural and kinetic properties of the enzyme were found close or identical to those of its skeletal muscle counterpart and other M-type lactate dehyd...

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Bibliographic Details
Published in:Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
Main Authors: Feller, Georges, Pauly, J. P., Smal, A., O'Carra, P., Gerday, Charles
Format: Article in Journal/Newspaper
Language:English
Published: Elsevier 1991
Subjects:
Life sciences
Biochemistry
biophysics & molecular biology
Sciences du vivant
Biochimie
biophysique & biologie moléculaire
Antarctic
Antarc*
Icefish
Online Access:https://orbi.uliege.be/handle/2268/16444
https://doi.org/10.1016/0167-4838(91)90079-F
Description
Summary:peer reviewed Cardiac lactate dehydrogenase from the hemoglobin- and myoglobin-free antarctic icefish has been purified by affinity chromatography. Structural and kinetic properties of the enzyme were found close or identical to those of its skeletal muscle counterpart and other M-type lactate dehydrogenases. A model involving a dual oxidative-anaerobic metabolism of the icefish heart is proposed.

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