Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti

Funding Information: This research was funded by University of Iceland Research Fund (Doctoral Grant and Project Grant), grant numbers not available, AVS R&D Fund of Ministry of Fisheries and Agriculture in Iceland, grant number R 029-14, the Landspitali University Hospital Research Fund (grant...

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Bibliographic Details
Published in:Molecules
Main Authors: Di, Xiaxia, Harðardóttir, Ingibjörg, Freysdóttir, Jóna, Wang, Dongdong, Gustafson, Kirk R, Ómarsdóttir, Sesselja Sigurborg, Molinski, Tadeusz F
Other Authors: Faculty of Medicine, Clinical Laboratory Services, Diagnostics and Blood Bank, Other departments, Faculty of Pharmaceutical Sciences
Format: Article in Journal/Newspaper
Language:English
Published: 2023
Subjects:
Náttúrufræðingar
Animals
Humans
Geodia/chemistry
Alkaloids/pharmacology
Cytokines
Anti-Inflammatory Agents
Molecular Structure
dendritic cells
Geodia barretti
herbipoline
6-bromoindole
anti-inflammatory activity
Drug Discovery
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Physical and Theoretical Chemistry
Pharmaceutical Science
Organic Chemistry
Iceland
Online Access:https://hdl.handle.net/20.500.11815/4152
https://doi.org/10.3390/molecules28072937
Description
Summary:Funding Information: This research was funded by University of Iceland Research Fund (Doctoral Grant and Project Grant), grant numbers not available, AVS R&D Fund of Ministry of Fisheries and Agriculture in Iceland, grant number R 029-14, the Landspitali University Hospital Research Fund (grant number not available), and the National Institutes of Health (AI100776, AT009783, to T.F.M.). Publisher Copyright: © 2023 by the authors. Geobarrettin D (1), a new bromoindole alkaloid, was isolated from the marine sponge Geodia barretti collected from Icelandic waters. Its structure was elucidated by 1D, and 2D NMR (including 1H-15N HSQC, 1H-15N HMBC spectra), as well as HRESIMS data. Geobarrettin D (1) is a new 6-bromoindole featuring an unusual purinium herbipoline moiety. Geobarrettin D (1) decreased secretion of the pro-inflammatory cytokine IL-12p40 by human monocyte derived dendritic cells, without affecting secretion of the anti-inflammatory cytokine IL-10. Thus, compound 1 shows anti-inflammatory activity. Peer reviewed

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