Asthma, allergic rhinitis and atopic dermatitis in association with home environment - The RHINE study

• Published in: Science of The Total Environment
• Main Authors: Wang, Juan, Janson, Christer, Malinovschi, Andrei, Holm, Mathias, Franklin, Karl A., Modig, Lars, Johannessen, Ane, Schlünssen, Vivi, Gíslason, Þórarinn, Jogi, Nils Oskar, Norbäck, Dan
• Other Authors: Internal Medicine and Emergency Services
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2022
• Subjects: Lungnalæknisfræði; Humans; Dermatitis; Atopic/epidemiology; Home Environment; Humidity; Rhinitis; Allergic/epidemiology; Asthma/epidemiology; Fungi; Europe; Risk Factors; Indoor painting; Asthma; Atopic dermatitis; Allergic rhinitis; Dampness; Pollution; Waste Management and Disposal; Environmental Engineering; Environmental Chemistry; Norway; Iceland
• Online Access: https://hdl.handle.net/20.500.11815/3719; https://doi.org/10.1016/j.scitotenv.2022.158609

Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved. Funding Information: The work was supported by the Icelandic Research Council , the Swedish Heart and Lung Foundation , the Vårdal Foundation for Health Care and Allergic Research , the Swedish Association Against Asthma and Allergy , the Swedish Council for Work Life and Social Research , the Swedish AFA Insurance (No. 467801100 ), the Bror Hjerpstedt Foundation , the Norwegian Research Council , the Norwegian Asthma and Allergy Association , the Danish Lung Association and the Estonian Science Foundation . Publisher Copyright: © 2022 We studied home environment exposures in relation to asthma, allergic rhinitis and atopic dermatitis among offspring of participants (parents) in the Respiratory Health in Northern Europe (RHINE) study (age ≤ 30 y). Totally 17,881 offspring from Iceland, Norway, Sweden, Denmark and Estonia were included. Home environment exposures, including dampness and mold, type of dwelling, construction year and indoor painting were registered through a questionnaire answered by parents in the first follow up (RHINE II). The parents reported ten years later with in the frame of RHINE III offspring's birth year and offspring's asthma, allergic rhinitis, atopic dermatitis. They also reported dampness and mold at home from RHINE II to RHINE III. The prevalence of offspring's asthma before 10 y, asthma after 10 y, allergic rhinitis at any age and atopic dermatitis at any age were 9.7 %, 4.3 %, 15.6 % and 17.3 %, respectively. Asthma before 10 y was related to any indoor painting at RHINE II (OR = 1.14, 95%CI (1.02, 1.29)). Asthma after 10 y was associated with dampness/mold at home (OR = 1.33-1.62) and living in the newest buildings (constructed in 1986-2001) (OR = 1.30, 95%CI (1.02, 1.66)). Allergic rhinitis was associated with living in newer buildings (constructed in 1961-2001) (OR = 1.16-1.24). Atopic dermatitis was associated with visible mold (OR = 1.35, 95%CI(1.12, 1.62)), dampness/mold at home (OR = 1.18-1.38), ...