Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010–2018
This work has been made possible by funding from Region Östergötland and VINNOVA Sweden's innovation agency. Publisher Copyright: © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. BACKGROUND: The Nordic countries have comparable nationwide antibiotic...
Published in: | Infectious Diseases |
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2021
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Online Access: | https://hdl.handle.net/20.500.11815/2942 https://doi.org/10.1080/23744235.2021.1910338 |
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Fræðsluefni Sýklalyfjaónæmi Norðurlönd Antibiotic resistance antibiotic stewardship Nordic countries practice guidelines as topic Humans Norway/epidemiology Anti-Bacterial Agents/pharmacology Methicillin-Resistant Staphylococcus aureus Finland/epidemiology Drug Resistance Microbial Sweden Hospitals Iceland/epidemiology Microbiology (medical) Infectious Diseases Immunology and Microbiology (all) |
spellingShingle |
Fræðsluefni Sýklalyfjaónæmi Norðurlönd Antibiotic resistance antibiotic stewardship Nordic countries practice guidelines as topic Humans Norway/epidemiology Anti-Bacterial Agents/pharmacology Methicillin-Resistant Staphylococcus aureus Finland/epidemiology Drug Resistance Microbial Sweden Hospitals Iceland/epidemiology Microbiology (medical) Infectious Diseases Immunology and Microbiology (all) Möller, Vidar Östholm-Balkhed, Åse Berild, Dag Fredriksson, Mats Gottfreðsson, Magnús Holmbom, Martin Järvinen, Asko Kristjánsson, Már Rydell, Ulf Sönksen, Ute Wolff Kolmos, Hans Joern Hanberger, Håkan Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010–2018 |
topic_facet |
Fræðsluefni Sýklalyfjaónæmi Norðurlönd Antibiotic resistance antibiotic stewardship Nordic countries practice guidelines as topic Humans Norway/epidemiology Anti-Bacterial Agents/pharmacology Methicillin-Resistant Staphylococcus aureus Finland/epidemiology Drug Resistance Microbial Sweden Hospitals Iceland/epidemiology Microbiology (medical) Infectious Diseases Immunology and Microbiology (all) |
description |
This work has been made possible by funding from Region Östergötland and VINNOVA Sweden's innovation agency. Publisher Copyright: © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. BACKGROUND: The Nordic countries have comparable nationwide antibiotic resistance surveillance systems and individual antibiotic stewardship programmes. The aim of this study was to assess antibiotic resistance among major pathogens in relation to practice guidelines for hospital antibiotic treatment and antibiotic use in Nordic countries 2010-2018. METHODS: Antibiotic resistance among invasive isolates from 2010-2018 and aggregated antibiotic use were obtained from the European Centre for Disease Prevention and Control. Hospital practice guidelines were obtained from national or regional guidelines. RESULTS: Antibiotic resistance levels among Escherichia coli and Klebsiella pneumoniae were similar in all Nordic countries in 2018 and low compared to the European mean. Guidelines for acute pyelonephritis varied; 2nd generation cephalosporin (Finland), 3rd generation cephalosporins (Sweden, Norway), ampicillin with an aminoglycoside or aminoglycoside monotherapy (Denmark, Iceland and Norway). Corresponding guidelines for sepsis of unknown origin were 2nd (Finland) or 3rd (Sweden, Norway, Iceland) generation cephalosporins, carbapenems, (Sweden) combinations of penicillin with an aminoglycoside (Norway, Denmark), or piperacillin-tazobactam (all Nordic countries). Methicillin-resistant Staphylococcus aureus rates were 0-2% and empirical treatment with anti-MRSA antibiotics was not recommended in any country. Rates of penicillin non-susceptibility among Streptococcus pneumoniae were low (<10%) except in Finland and Iceland (<15%), but benzylpenicillin was recommended for community-acquired pneumonia in all countries. CONCLUSION: Despite similar resistance rates among Enterobacteriaceae there were differences in practice guidelines for pyelonephritis and sepsis. National surveillance of ... |
author2 |
Faculty of Medicine Other departments Internal Medicine and Emergency Services Landspitali - The National University Hospital of Iceland |
format |
Article in Journal/Newspaper |
author |
Möller, Vidar Östholm-Balkhed, Åse Berild, Dag Fredriksson, Mats Gottfreðsson, Magnús Holmbom, Martin Järvinen, Asko Kristjánsson, Már Rydell, Ulf Sönksen, Ute Wolff Kolmos, Hans Joern Hanberger, Håkan |
author_facet |
Möller, Vidar Östholm-Balkhed, Åse Berild, Dag Fredriksson, Mats Gottfreðsson, Magnús Holmbom, Martin Järvinen, Asko Kristjánsson, Már Rydell, Ulf Sönksen, Ute Wolff Kolmos, Hans Joern Hanberger, Håkan |
author_sort |
Möller, Vidar |
title |
Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010–2018 |
title_short |
Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010–2018 |
title_full |
Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010–2018 |
title_fullStr |
Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010–2018 |
title_full_unstemmed |
Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010–2018 |
title_sort |
antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in nordic hospitals 2010–2018 |
publishDate |
2021 |
url |
https://hdl.handle.net/20.500.11815/2942 https://doi.org/10.1080/23744235.2021.1910338 |
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Norway |
geographic_facet |
Norway |
genre |
Iceland |
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Iceland |
op_relation |
Infectious Diseases; 53(8) http://www.scopus.com/inward/record.url?scp=85106010651&partnerID=8YFLogxK Möller , V , Östholm-Balkhed , Å , Berild , D , Fredriksson , M , Gottfreðsson , M , Holmbom , M , Järvinen , A , Kristjánsson , M , Rydell , U , Sönksen , U W , Kolmos , H J & Hanberger , H 2021 , ' Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010–2018 ' , Infectious Diseases , vol. 53 , no. 8 , pp. 607-618 . https://doi.org/10.1080/23744235.2021.1910338 2374-4235 38960008 c0882f40-dfb8-4aad-9651-cb96e738a487 85106010651 33970737 unpaywall: 10.1080/23744235.2021.1910338 https://hdl.handle.net/20.500.11815/2942 doi:10.1080/23744235.2021.1910338 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.11815/294210.1080/23744235.2021.1910338 |
container_title |
Infectious Diseases |
container_volume |
53 |
container_issue |
8 |
container_start_page |
607 |
op_container_end_page |
618 |
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1782335624879013888 |
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ftopinvisindi:oai:opinvisindi.is:20.500.11815/2942 2023-11-12T04:19:07+01:00 Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010–2018 Möller, Vidar Östholm-Balkhed, Åse Berild, Dag Fredriksson, Mats Gottfreðsson, Magnús Holmbom, Martin Järvinen, Asko Kristjánsson, Már Rydell, Ulf Sönksen, Ute Wolff Kolmos, Hans Joern Hanberger, Håkan Faculty of Medicine Other departments Internal Medicine and Emergency Services Landspitali - The National University Hospital of Iceland 2021-05-10 12 2344643 607-618 https://hdl.handle.net/20.500.11815/2942 https://doi.org/10.1080/23744235.2021.1910338 en eng Infectious Diseases; 53(8) http://www.scopus.com/inward/record.url?scp=85106010651&partnerID=8YFLogxK Möller , V , Östholm-Balkhed , Å , Berild , D , Fredriksson , M , Gottfreðsson , M , Holmbom , M , Järvinen , A , Kristjánsson , M , Rydell , U , Sönksen , U W , Kolmos , H J & Hanberger , H 2021 , ' Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010–2018 ' , Infectious Diseases , vol. 53 , no. 8 , pp. 607-618 . https://doi.org/10.1080/23744235.2021.1910338 2374-4235 38960008 c0882f40-dfb8-4aad-9651-cb96e738a487 85106010651 33970737 unpaywall: 10.1080/23744235.2021.1910338 https://hdl.handle.net/20.500.11815/2942 doi:10.1080/23744235.2021.1910338 info:eu-repo/semantics/openAccess Fræðsluefni Sýklalyfjaónæmi Norðurlönd Antibiotic resistance antibiotic stewardship Nordic countries practice guidelines as topic Humans Norway/epidemiology Anti-Bacterial Agents/pharmacology Methicillin-Resistant Staphylococcus aureus Finland/epidemiology Drug Resistance Microbial Sweden Hospitals Iceland/epidemiology Microbiology (medical) Infectious Diseases Immunology and Microbiology (all) /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article 2021 ftopinvisindi https://doi.org/20.500.11815/294210.1080/23744235.2021.1910338 2023-11-01T23:55:18Z This work has been made possible by funding from Region Östergötland and VINNOVA Sweden's innovation agency. Publisher Copyright: © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. BACKGROUND: The Nordic countries have comparable nationwide antibiotic resistance surveillance systems and individual antibiotic stewardship programmes. The aim of this study was to assess antibiotic resistance among major pathogens in relation to practice guidelines for hospital antibiotic treatment and antibiotic use in Nordic countries 2010-2018. METHODS: Antibiotic resistance among invasive isolates from 2010-2018 and aggregated antibiotic use were obtained from the European Centre for Disease Prevention and Control. Hospital practice guidelines were obtained from national or regional guidelines. RESULTS: Antibiotic resistance levels among Escherichia coli and Klebsiella pneumoniae were similar in all Nordic countries in 2018 and low compared to the European mean. Guidelines for acute pyelonephritis varied; 2nd generation cephalosporin (Finland), 3rd generation cephalosporins (Sweden, Norway), ampicillin with an aminoglycoside or aminoglycoside monotherapy (Denmark, Iceland and Norway). Corresponding guidelines for sepsis of unknown origin were 2nd (Finland) or 3rd (Sweden, Norway, Iceland) generation cephalosporins, carbapenems, (Sweden) combinations of penicillin with an aminoglycoside (Norway, Denmark), or piperacillin-tazobactam (all Nordic countries). Methicillin-resistant Staphylococcus aureus rates were 0-2% and empirical treatment with anti-MRSA antibiotics was not recommended in any country. Rates of penicillin non-susceptibility among Streptococcus pneumoniae were low (<10%) except in Finland and Iceland (<15%), but benzylpenicillin was recommended for community-acquired pneumonia in all countries. CONCLUSION: Despite similar resistance rates among Enterobacteriaceae there were differences in practice guidelines for pyelonephritis and sepsis. National surveillance of ... Article in Journal/Newspaper Iceland Opin vísindi (Iceland) Norway Infectious Diseases 53 8 607 618 |