A shared genetic contribution to breast cancer and schizophrenia

Publisher's version (útgefin grein) An association between schizophrenia and subsequent breast cancer has been suggested; however the risk of schizophrenia following a breast cancer is unknown. Moreover, the driving forces of the link are largely unclear. Here, we report the phenotypic and gene...

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Bibliographic Details
Published in:Nature Communications
Main Authors: Lu, Donghao, Song, Jie, Lu, Yi, Fall, Katja, Chen, Xu, Fang, Fang, Landén, Mikael, Hultman, Christina M., Czene, Kamila, Sullivan, Patrick, Tamimi, Rulla M., Valdimarsdottir, Unnur
Other Authors: Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland
Format: Article in Journal/Newspaper
Language:English
Published: Springer Science and Business Media LLC 2020
Subjects:
Schizophrenia
Breast cancer
Phenotype
Geðklofi
Brjóstakrabbamein
Arfgengi
Erfðarannsóknir
Iceland
Online Access:https://hdl.handle.net/20.500.11815/2131
https://doi.org/10.1038/s41467-020-18492-8
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Summary:Publisher's version (útgefin grein) An association between schizophrenia and subsequent breast cancer has been suggested; however the risk of schizophrenia following a breast cancer is unknown. Moreover, the driving forces of the link are largely unclear. Here, we report the phenotypic and genetic positive associations of schizophrenia with breast cancer and vice versa, based on a Swedish population-based cohort and GWAS data from international consortia. We observe a genetic correlation of 0.14 (95% CI 0.09–0.19) and identify a shared locus at 19p13 (GATAD2A) associated with risks of breast cancer and schizophrenia. The epidemiological bidirectional association between breast cancer and schizophrenia may partly be explained by the genetic overlap between the two phenotypes and, hence, shared biological mechanisms. This work is supported by the Swedish Research Council (grant number: 2018-00648, to D.L.), Karolinska Institutet Research Foundation (grant number: 2018-01585, to D.L.), Grant of Excellence, Icelandic Research Fund (grant number 163362-051, to U.A.V.), and ERC Consolidator Grant (StressGene, grant number:726413, to U.A.V.). We thank Dr. Agnar Helgason, Dr. Patrick Sulem, and Dr. Kári Stefánsson from deCODE Genetics, Iceland for helpful discussions on data analysis and interpretations. We also acknowledge the shared GWAS statistical summaries of schizophrenia from the Psychiatric Genetics Consortium and breast cancer from the Breast Cancer Association Consortium. Peer Reviewed

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