Electrospun Nanofibers for Entrapment of Biomolecules
This chapter focuses on nanofiber fabrication by electrospinning techniques for the effective immobilization of biomolecules (such as enzymes or active pharmaceutical ingredients—APIs). In this chapter, the development of precursor materials (from commercial polymer systems to systematically designe...
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| Format: | Book Part |
| Language: | English |
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IntechOpen
2018
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| Online Access: | https://openresearchlibrary.org/viewer/a29f7488-ab03-4664-a0b7-36a35bf82f30 https://openresearchlibrary.org/ext/api/media/a29f7488-ab03-4664-a0b7-36a35bf82f30/assets/external_content.pdf https://doi.org/10.5772/intechopen.76068 |
| Summary: | This chapter focuses on nanofiber fabrication by electrospinning techniques for the effective immobilization of biomolecules (such as enzymes or active pharmaceutical ingredients—APIs). In this chapter, the development of precursor materials (from commercial polymer systems to systematically designed biopolymers), entrapment protocols, and precursor-nanofiber characterization methods are represented. The entrapment ability of poly(vinyl alcohol) and systematically modified polyaspartamide nanofibers was investigated for immobilization of two different lipases (from Candida antarctica and Pseudomonas fluorescens) and for formulation of the antibacterial and antiviral agent, rifampicin. The encapsulated biomolecules in electrospun polymer fibers could be promising nanomaterials for industrial biocatalysis to produce chiral compound or in the development of smart drug delivery systems. |
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