Studying the metabolism of toxic chemical warfare agent-related phenylarsenic chemicals in vitro in cod liver
Large quantities of chemical warfare agents (CWAs), such as phenylarsenic chemicals, were disposed by seadumping after World War II. Nowadays, the release of these toxic chemicals from munitions poses a potential threat to living organisms. This study investigates the fate of these chemicals in fish...
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ftopenagrar:oai:www.openagrar.de:openagrar_mods_00064436 2023-05-15T16:19:15+02:00 Studying the metabolism of toxic chemical warfare agent-related phenylarsenic chemicals in vitro in cod liver Niemikoski, Hanna Koske, Daniel Kammann, Ulrike Lang, Thomas Vanninen, Paula 2020 https://doi.org/10.1016/j.jhazmat.2020.122221 https://www.openagrar.de/receive/openagrar_mods_00064436 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00033558/dn062096.pdf eng eng Journal of Hazardous Materials -- J. HAZARD. MATERIALS -- 0304-3894 -- 1873-3336 -- 195278-x -- 1491302-1 https://doi.org/10.1016/j.jhazmat.2020.122221 https://www.openagrar.de/receive/openagrar_mods_00064436 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00033558/dn062096.pdf only signed in user all rights reserved info:eu-repo/semantics/openAccess Text ddc:570 Chemical warfare agent -- Arsenic -- Fish -- In vitro metabolism -- High-resolution mass spectrometry article Text 2020 ftopenagrar https://doi.org/10.1016/j.jhazmat.2020.122221 2023-03-06T00:09:34Z Large quantities of chemical warfare agents (CWAs), such as phenylarsenic chemicals, were disposed by seadumping after World War II. Nowadays, the release of these toxic chemicals from munitions poses a potential threat to living organisms. This study investigates the fate of these chemicals in fish by exposing selected CWArelated phenylarsenic chemicals and their oxidation products to cod (Gadus morhua) liver S9 fraction in vitro. Clark I (DA), Adamsite (DM) and their corresponding oxidation products as well as triphenylarsine oxide (TPA[ox]) and phenylarsonic acid (PDCA[ox]) were used as chemicals in in vitro experiments. Glutathione (GSH) conjugates of DA, DM and PDCA-related chemicals were found to be the most dominant metabolites, and methylated metabolites were detected as well, suggesting that these compounds are metabolised in the presence of cod liver enzymes. TPA[ox] was the only compound tested that did not form a GSH conjugate or methylated metabolite, indicating a different biotransformation pathway for this compound. Furthermore, hydroxylated metabolites were detected for each tested chemical. Due to their reactive nature, GSH conjugates may be difficult to detect in fish samples from CWA dumpsites. In contrast, both methylated and hydroxylated metabolites of phenylarsenic chemicals are promising target chemicals for the detection of CWA-related contamination in fish. Article in Journal/Newspaper Gadus morhua OpenAgrar (OA) Journal of Hazardous Materials 391 122221 |
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Open Polar |
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OpenAgrar (OA) |
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ftopenagrar |
language |
English |
topic |
Text ddc:570 Chemical warfare agent -- Arsenic -- Fish -- In vitro metabolism -- High-resolution mass spectrometry |
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Text ddc:570 Chemical warfare agent -- Arsenic -- Fish -- In vitro metabolism -- High-resolution mass spectrometry Niemikoski, Hanna Koske, Daniel Kammann, Ulrike Lang, Thomas Vanninen, Paula Studying the metabolism of toxic chemical warfare agent-related phenylarsenic chemicals in vitro in cod liver |
topic_facet |
Text ddc:570 Chemical warfare agent -- Arsenic -- Fish -- In vitro metabolism -- High-resolution mass spectrometry |
description |
Large quantities of chemical warfare agents (CWAs), such as phenylarsenic chemicals, were disposed by seadumping after World War II. Nowadays, the release of these toxic chemicals from munitions poses a potential threat to living organisms. This study investigates the fate of these chemicals in fish by exposing selected CWArelated phenylarsenic chemicals and their oxidation products to cod (Gadus morhua) liver S9 fraction in vitro. Clark I (DA), Adamsite (DM) and their corresponding oxidation products as well as triphenylarsine oxide (TPA[ox]) and phenylarsonic acid (PDCA[ox]) were used as chemicals in in vitro experiments. Glutathione (GSH) conjugates of DA, DM and PDCA-related chemicals were found to be the most dominant metabolites, and methylated metabolites were detected as well, suggesting that these compounds are metabolised in the presence of cod liver enzymes. TPA[ox] was the only compound tested that did not form a GSH conjugate or methylated metabolite, indicating a different biotransformation pathway for this compound. Furthermore, hydroxylated metabolites were detected for each tested chemical. Due to their reactive nature, GSH conjugates may be difficult to detect in fish samples from CWA dumpsites. In contrast, both methylated and hydroxylated metabolites of phenylarsenic chemicals are promising target chemicals for the detection of CWA-related contamination in fish. |
format |
Article in Journal/Newspaper |
author |
Niemikoski, Hanna Koske, Daniel Kammann, Ulrike Lang, Thomas Vanninen, Paula |
author_facet |
Niemikoski, Hanna Koske, Daniel Kammann, Ulrike Lang, Thomas Vanninen, Paula |
author_sort |
Niemikoski, Hanna |
title |
Studying the metabolism of toxic chemical warfare agent-related phenylarsenic chemicals in vitro in cod liver |
title_short |
Studying the metabolism of toxic chemical warfare agent-related phenylarsenic chemicals in vitro in cod liver |
title_full |
Studying the metabolism of toxic chemical warfare agent-related phenylarsenic chemicals in vitro in cod liver |
title_fullStr |
Studying the metabolism of toxic chemical warfare agent-related phenylarsenic chemicals in vitro in cod liver |
title_full_unstemmed |
Studying the metabolism of toxic chemical warfare agent-related phenylarsenic chemicals in vitro in cod liver |
title_sort |
studying the metabolism of toxic chemical warfare agent-related phenylarsenic chemicals in vitro in cod liver |
publishDate |
2020 |
url |
https://doi.org/10.1016/j.jhazmat.2020.122221 https://www.openagrar.de/receive/openagrar_mods_00064436 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00033558/dn062096.pdf |
genre |
Gadus morhua |
genre_facet |
Gadus morhua |
op_relation |
Journal of Hazardous Materials -- J. HAZARD. MATERIALS -- 0304-3894 -- 1873-3336 -- 195278-x -- 1491302-1 https://doi.org/10.1016/j.jhazmat.2020.122221 https://www.openagrar.de/receive/openagrar_mods_00064436 https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00033558/dn062096.pdf |
op_rights |
only signed in user all rights reserved info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.jhazmat.2020.122221 |
container_title |
Journal of Hazardous Materials |
container_volume |
391 |
container_start_page |
122221 |
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1766005609737486336 |