Hemostatic side effects of high-dose methotrexate in childhood acute lymphoblastic leukemia

WOS: 000186930500010 PubMed: 14660309 The purpose of this study is to investigate the hemostatic side effects of HDMTX. Between 2001 and 2002, 20 children with acute lymphoblastic leukemia at the Dr. Sami Ulus Children's Hospital, Department of Pediatric Hematology and Oncology, treated accordi...

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Bibliographic Details
Published in:Pediatric Hematology and Oncology
Main Authors: Fisgin, T, Yarali, N, Kara, A, Bozkurt, C, Birgen, D, Erten, U, Duru, F
Other Authors: Ondokuz Mayıs Üniversitesi
Format: Article in Journal/Newspaper
Language:English
Published: Taylor & Francis Inc 2004
Subjects:
sami
Online Access:https://hdl.handle.net/20.500.12712/21652
https://doi.org/10.1080/08880010490264064
Description
Summary:WOS: 000186930500010 PubMed: 14660309 The purpose of this study is to investigate the hemostatic side effects of HDMTX. Between 2001 and 2002, 20 children with acute lymphoblastic leukemia at the Dr. Sami Ulus Children's Hospital, Department of Pediatric Hematology and Oncology, treated according to the St. Jude ALL XIII protocol were eligible to this study. Methotrexate at a dose of 2 g/m(2) was infused over 24 hours. Coagulation screening studies included prothrombin time (PT), APTT, fibrinogen, fibrin degradation product ( D -Dimer), factor II, factor V, factor VII, factor VIII, factor IX, factor X, PC, PS, AT-III determinations before HDMTX therapy (PreT), 1 day after (PostT 1D ), and 1 week after (PostT(1W) ) the end of the HDMTX infusion. We found that PT and APTT were prolonged, PC, PS, and AT-III levels were decreased with a slight increase in D -Dimer 1 day after the administration of HDMTX and all of them returned to the normal levels by 7 days. In addition we found that FVII, FIX, FX were significantly decreased 1 day after therapy and normalised by 7 days.

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