Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids

• Published in: New Biotechnology
• Main Authors: Theodosiou, E, Loutrari, H, Stamatis, H, Roussos, C, Kolisis, FN
• Language: unknown
• Published: 2011
• Subjects: Antitumor Activity; Dicarboxylic Acid; Acyl donors; Anti-angiogenic activity; Anti-tumor activities; Anti-tumors; Antiproliferative effect; Biocatalytic synthesis; Biological functions; Candida antarctica lipase B; Monoesters; Novozym435; Reaction parameters; Silybin; Vascular endothelial growth factor; Endothelial cells; Organic compounds; Organic solvents; Synthesis (chemical); Acylation; dicarboxylic acid derivative; ester; lipase B; silibinin; vasculotropin; antiangiogenic activity; antineoplastic activity; article; cancer cell; Candida antarctica; catalysis; drug structure; drug synthesis; lymphoblastoma; priority journal; solvent extraction; Acetylation; Antineoplastic Agents; Cell Survival; Dicarboxylic Acids; Humans; K562 Cells; Lipase; Silymarin; Antarc*; Antarctica
• Online Access: https://doi.org/10.1016/j.nbt.2011.01.006