Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative activity

• Published in: Biocatalysis and Biotransformation
• Main Authors: Theodosiou, E, Katsoura, MM, Loutrari, H, Purchartova, K, Kren, V, Kolisis, FN, Stamatis, H
• Language: unknown
• Published: 2009
• Subjects: Acylation; Antitumor proliferative activity; Ionic liquids; Lipase; Organic solvents; Silybin; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Acyl donors; Alkyl chain lengths; Anti-tumors; Antiproliferative effect; Biocatalytic preparation; Biocatalytic process; Candida antarctica lipase B; Conversion yield; Enzymatic preparation; Enzymatic process; Free fatty acid; Human leukemia cells; Imidazolium-based ionic liquid; Ionic liquid media; Molar ratio; Proliferative activity; Reaction media; Acetone; Esterification; Esters; Fatty acids; Ionization of liquids; Negative ions; Reaction rates; antineoplastic agent; flavonolignan; imidazole derivative; ionic liquid; lipase B; organic solvent; silibinin; silybin 23 o butanoate; silybin 23 o laurate; silybin 23 o oleate; unclassified drug; antineoplastic activity; Antarc*; Antarctica
• Online Access: https://doi.org/10.1080/10242420902937777