Immobilization does not influence the enantioselectivity of CAL-B catalyzed kinetic resolution of secondary alcohols

Decreasing enantioselectivity (E-value) by conversion has been observed in transesterification reactions of secondary alcohols catalyzed by a pure protein formulation of lipase B from Candida antarctica (Novozym 525 F). Addition of a range of enantiopure alcohols caused a temporary increase in enzym...

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Bibliographic Details
Published in:Tetrahedron: Asymmetry
Main Authors: Jacobsen, Elisabeth Egholm, Andresen, Liv Siri, Anthonsen, Thorleif
Format: Article in Journal/Newspaper
Language:English
Published: Elsevier 2005
Subjects:
Antarc*
Antarctica
Online Access:http://hdl.handle.net/11250/2432641
https://doi.org/10.1016/j.tetasy.2004.11.081
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Summary:Decreasing enantioselectivity (E-value) by conversion has been observed in transesterification reactions of secondary alcohols catalyzed by a pure protein formulation of lipase B from Candida antarctica (Novozym 525 F). Addition of a range of enantiopure alcohols caused a temporary increase in enzyme selectivity in the transesterification reaction of 3-chloro-1-phenoxy-2-propanol with vinyl butanoate. Author preprint. © 2004 Elsevier Ltd. All rights reserved

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