Differential expression of the pro-inflammatory cytokinesIL-1ÃͶ-1, TNFa and IL-8 in vaccinated pink (Oncorhynchus gorbuscha) and chum (Oncorhynchus keta) salmon juveniles

Laboratory-reared pink and chum salmon juveniles (2 g) received an intraperitoneal injection with a commercial, unadjuvanted Aeromonas salmonicida bacterin or sterile saline. Relative to elongation factor-1A, expression levels of genes encoding the proinflammatory cytokines interleukin-1?-1 (IL-1?),...

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Bibliographic Details
Published in:Fish & Shellfish Immunology
Main Authors: Fast, M. D., Johnson, S. C., Jones, S. R. M.
Format: Article in Journal/Newspaper
Language:English
Published: Elsevier 2007
Subjects:
vaccination
juvenile salmon
inflammatory
gene expression
anadromous species
bacterial diseases
bacterins
elongation
fish diseases
fish physiology
immune response
inflammation
Oncorhynchus gorbuscha
Oncorhynchus keta
Aeromonas salmonicida
liver
kidney
tumor necrosis factor- alpha
tumours
juveniles
interleukin 8
interleukin 1
Keta
Pink salmon
Online Access:https://doi.org/10.1016/j.fsi.2006.06.012
https://nrc-publications.canada.ca/eng/view/object/?id=bd741699-4196-4384-95e8-3fd8dac858d5
https://nrc-publications.canada.ca/fra/voir/objet/?id=bd741699-4196-4384-95e8-3fd8dac858d5
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Summary:Laboratory-reared pink and chum salmon juveniles (2 g) received an intraperitoneal injection with a commercial, unadjuvanted Aeromonas salmonicida bacterin or sterile saline. Relative to elongation factor-1A, expression levels of genes encoding the proinflammatory cytokines interleukin-1?-1 (IL-1?), tumour necrosis factor-?-1 (TNF?) and interleukin-8 (IL-8) in pools of kidney and liver were examined 6- and 24-h after injection. Expression of IL-1? was significantly elevated in pink and chum salmon by 6-h, and declined in pink salmon but not in chum salmon by 24-h. Similarly, expression of TNF? was significantly elevated in both species at 6 h and only in chum salmon after 24-h. Expression of IL-8 was significantly elevated in both species at 6- and 24-h after injection. Expression of the three proinflammatory cytokine genes differed between salmon species both in the timing and magnitude of their expression. The significance of these differences with respect to immune function in these fish requires further research. yes Peer reviewed: Yes NRC publication: Yes

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