Ring-opening polymerization of bile acid macrocycles by Candida antarctica lipase B

Lipase-catalyzed polymerization was explored as an alternative for Ru-catalyzed ring opening metathesis polymerization in the synthesis of polyesters bearing large functional moieties as part of the main chain. The selectivity of Candida antarctica lipase B (CALB) towards the functional groups of ch...

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Bibliographic Details
Published in:Polymer Chemistry
Main Authors: Strandman, Satu, Tsai, I-Huang, Lortie, Robert, Zhu, X. X.
Format: Article in Journal/Newspaper
Language:English
Published: RSC Publishing 2013
Subjects:
Body temperature
Candida antarctica lipase B
Cholic acids
Functional moieties
Lipase-catalyzed
Macrocycles
Ring opening metathesis polymerization
Rubber-like elasticities
Antarc*
Antarctica
Online Access:https://doi.org/10.1039/c3py00651d
https://nrc-publications.canada.ca/eng/view/object/?id=de349e4a-b174-41c1-b756-508c28bf1443
https://nrc-publications.canada.ca/fra/voir/objet/?id=de349e4a-b174-41c1-b756-508c28bf1443
Description
Summary:Lipase-catalyzed polymerization was explored as an alternative for Ru-catalyzed ring opening metathesis polymerization in the synthesis of polyesters bearing large functional moieties as part of the main chain. The selectivity of Candida antarctica lipase B (CALB) towards the functional groups of cholic acid (CA) was demonstrated, and the obtained CA-based polymers had relatively high molar masses, rubber-like elasticity, and glass transitions close to body temperature. Peer reviewed: Yes NRC publication: Yes

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