Nasal responses to elevated temperature and Francisella noatunensis infection in Atlantic cod (Gadus morhua)
We report the histological and transcriptomic changes in the olfactory organ of Atlantic cod exposed to Francisella noatunensis. Experimental infection was performed at either 12oC or 17oC. Infected fish presented the classic gross pathologies of francisellosis. Nasal morpho-phenotypic parameters we...
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Online Access: | https://hdl.handle.net/11250/3102288 https://doi.org/10.1016/j.ygeno.2023.110735 |
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ftnofima:oai:nofima.brage.unit.no:11250/3102288 2023-12-10T09:46:30+01:00 Nasal responses to elevated temperature and Francisella noatunensis infection in Atlantic cod (Gadus morhua) Lazado, Carlo C. Iversen, Marianne Johansen, Lill-Heidi Brenne, Hanne Britt Sundaram, Arvind Ytteborg, Elisabeth 2023 application/pdf https://hdl.handle.net/11250/3102288 https://doi.org/10.1016/j.ygeno.2023.110735 eng eng Troms Fylkeskommune: TFFK2021-179 Norges forskningsråd: 194050 Genomics. 2023, 1-40. urn:issn:0888-7543 https://hdl.handle.net/11250/3102288 https://doi.org/10.1016/j.ygeno.2023.110735 cristin:2188572 1-40 Genomics VDP::Generell immunologi: 478 VDP::General immunology: 478 Peer reviewed Journal article 2023 ftnofima https://doi.org/10.1016/j.ygeno.2023.110735 2023-11-15T23:50:45Z We report the histological and transcriptomic changes in the olfactory organ of Atlantic cod exposed to Francisella noatunensis. Experimental infection was performed at either 12oC or 17oC. Infected fish presented the classic gross pathologies of francisellosis. Nasal morpho-phenotypic parameters were not significantly affected by temperature and infection, except for the number of mucus cells in the 12oC group seven weeks after the challenge. A higher number of genes were altered through time in the group reared at 17oC. At termination, the nasal transcriptome of infected fish in both groups was similar to the control. When both infected groups were compared, 754 DEGs were identified, many of which were involved in signalling, defence, transmembrane and enzymatic processes. In conclusion, the study reveals that elevated temperature could trigger responses in the olfactory organ of Atlantic cod and shape the nasal response to F. noatunensis infection. Nasal responses to elevated temperature and Francisella noatunensis infection in Atlantic cod (Gadus morhua) publishedVersion Article in Journal/Newspaper atlantic cod Gadus morhua Nofima Knowledge Archive (Brage) Genomics 115 6 110735 |
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Open Polar |
collection |
Nofima Knowledge Archive (Brage) |
op_collection_id |
ftnofima |
language |
English |
topic |
VDP::Generell immunologi: 478 VDP::General immunology: 478 |
spellingShingle |
VDP::Generell immunologi: 478 VDP::General immunology: 478 Lazado, Carlo C. Iversen, Marianne Johansen, Lill-Heidi Brenne, Hanne Britt Sundaram, Arvind Ytteborg, Elisabeth Nasal responses to elevated temperature and Francisella noatunensis infection in Atlantic cod (Gadus morhua) |
topic_facet |
VDP::Generell immunologi: 478 VDP::General immunology: 478 |
description |
We report the histological and transcriptomic changes in the olfactory organ of Atlantic cod exposed to Francisella noatunensis. Experimental infection was performed at either 12oC or 17oC. Infected fish presented the classic gross pathologies of francisellosis. Nasal morpho-phenotypic parameters were not significantly affected by temperature and infection, except for the number of mucus cells in the 12oC group seven weeks after the challenge. A higher number of genes were altered through time in the group reared at 17oC. At termination, the nasal transcriptome of infected fish in both groups was similar to the control. When both infected groups were compared, 754 DEGs were identified, many of which were involved in signalling, defence, transmembrane and enzymatic processes. In conclusion, the study reveals that elevated temperature could trigger responses in the olfactory organ of Atlantic cod and shape the nasal response to F. noatunensis infection. Nasal responses to elevated temperature and Francisella noatunensis infection in Atlantic cod (Gadus morhua) publishedVersion |
format |
Article in Journal/Newspaper |
author |
Lazado, Carlo C. Iversen, Marianne Johansen, Lill-Heidi Brenne, Hanne Britt Sundaram, Arvind Ytteborg, Elisabeth |
author_facet |
Lazado, Carlo C. Iversen, Marianne Johansen, Lill-Heidi Brenne, Hanne Britt Sundaram, Arvind Ytteborg, Elisabeth |
author_sort |
Lazado, Carlo C. |
title |
Nasal responses to elevated temperature and Francisella noatunensis infection in Atlantic cod (Gadus morhua) |
title_short |
Nasal responses to elevated temperature and Francisella noatunensis infection in Atlantic cod (Gadus morhua) |
title_full |
Nasal responses to elevated temperature and Francisella noatunensis infection in Atlantic cod (Gadus morhua) |
title_fullStr |
Nasal responses to elevated temperature and Francisella noatunensis infection in Atlantic cod (Gadus morhua) |
title_full_unstemmed |
Nasal responses to elevated temperature and Francisella noatunensis infection in Atlantic cod (Gadus morhua) |
title_sort |
nasal responses to elevated temperature and francisella noatunensis infection in atlantic cod (gadus morhua) |
publishDate |
2023 |
url |
https://hdl.handle.net/11250/3102288 https://doi.org/10.1016/j.ygeno.2023.110735 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
1-40 Genomics |
op_relation |
Troms Fylkeskommune: TFFK2021-179 Norges forskningsråd: 194050 Genomics. 2023, 1-40. urn:issn:0888-7543 https://hdl.handle.net/11250/3102288 https://doi.org/10.1016/j.ygeno.2023.110735 cristin:2188572 |
op_doi |
https://doi.org/10.1016/j.ygeno.2023.110735 |
container_title |
Genomics |
container_volume |
115 |
container_issue |
6 |
container_start_page |
110735 |
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1784889951940247552 |