Nasal responses to elevated temperature and Francisella noatunensis infection in Atlantic cod (Gadus morhua)

We report the histological and transcriptomic changes in the olfactory organ of Atlantic cod exposed to Francisella noatunensis. Experimental infection was performed at either 12oC or 17oC. Infected fish presented the classic gross pathologies of francisellosis. Nasal morpho-phenotypic parameters we...

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Bibliographic Details
Published in:Genomics
Main Authors: Lazado, Carlo C., Iversen, Marianne, Johansen, Lill-Heidi, Brenne, Hanne Britt, Sundaram, Arvind, Ytteborg, Elisabeth
Format: Article in Journal/Newspaper
Language:English
Published: 2023
Subjects:
VDP::Generell immunologi: 478
VDP::General immunology: 478
atlantic cod
Gadus morhua
Online Access:https://hdl.handle.net/11250/3102288
https://doi.org/10.1016/j.ygeno.2023.110735
Description
Summary:We report the histological and transcriptomic changes in the olfactory organ of Atlantic cod exposed to Francisella noatunensis. Experimental infection was performed at either 12oC or 17oC. Infected fish presented the classic gross pathologies of francisellosis. Nasal morpho-phenotypic parameters were not significantly affected by temperature and infection, except for the number of mucus cells in the 12oC group seven weeks after the challenge. A higher number of genes were altered through time in the group reared at 17oC. At termination, the nasal transcriptome of infected fish in both groups was similar to the control. When both infected groups were compared, 754 DEGs were identified, many of which were involved in signalling, defence, transmembrane and enzymatic processes. In conclusion, the study reveals that elevated temperature could trigger responses in the olfactory organ of Atlantic cod and shape the nasal response to F. noatunensis infection. Nasal responses to elevated temperature and Francisella noatunensis infection in Atlantic cod (Gadus morhua) publishedVersion

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