Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers

• Published in: Scientific Reports
• Main Authors: F. Fernández, Sandra, Poteser, Michael, Govarts, Eva, Pardo, Olga, Coscollà, Clara, Schettgen, Thomas, Vogel, Nina, Weber, Till, Murawski, Aline, Kolossa-Gehring, Marike, Rüther, Maria, Schmidt, Phillipp, Namorado, Sónia, Van Nieuwenhuyse, An, Appenzeller, Brice, Ólafsdóttir, Kristín, Halldorsson, Thorhallur I., Haug, Line S., Thomsen, Cathrine, Barbone, Fabio, Mariuz, Marika, Rosolen, Valentina, Rambaud, Loïc, Riou, Margaux, Göen, Thomas, Nübler, Stefanie, Schäfer, Moritz, Zarrabi, Karin H.A., Sepai, Ovnair, Martin, Laura Rodriguez, Schoeters, Greet, Gilles, Liese, Leander, Karin, Moshammer, Hanns, Akesson, Agneta, Laguzzi, Federica
• Other Authors: Comprehensive Health Research Centre (CHRC) - Pólo ENSP, Centro de Investigação em Saúde Pública (CISP/PHRC), Escola Nacional de Saúde Pública (ENSP)
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2023
• Subjects: General; Norway; Iceland
• Online Access: http://hdl.handle.net/10362/167128; https://doi.org/10.1038/s41598-023-48738-6

The original version of this Article contained an error in the name of the author Federica Laguzzi, which was incorrectly given as Laguzzi Federica. https://doi.org/10.1038/s41598-024-52775-0 Funding Information: Open access funding provided by Karolinska Institute. This work was supported by the European Union Horizon-2020 Research and Innovation Programme under Grant Agreement No. 733032 (HBM4EU project). The funding of the German data by the German Ministry for the Environment, Nature Conservation, Nuclear Safety and Consumer Protection is gratefully acknowledged. The Norwegian Institute of Public Health (NIPH) has contributed to funding of the Norwegian Environmental Biobank (NEB). The laboratory measurements have partly been funded by the Research Council of Norway through research Projects (275903 and 268465). Funding Information: The authors thank all the partners of the HBM4EU project. Fernández S.F. acknowledges the CIBEFP/2021/51 funding provided by the Valencian Government (Spain) and the European Social Fund. We also thank Frumento P and Discacciati A. for their statistical support. Publisher Copyright: © 2023, The Author(s). Little is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed determinants of AA exposure, measured by urinary mercapturic acids of AA (AAMA) and glycidamide (GAMA), its main metabolite, in 3157 children/adolescents and 1297 adults in the European Human Biomonitoring Initiative. Harmonized individual-level questionnaires data and quality assured measurements of AAMA and GAMA (urine collection: 2014–2021), the short-term validated biomarkers of AA exposure, were obtained from four studies (Italy, France, Germany, and Norway) in children/adolescents (age range: 3–18 years) and six studies (Portugal, Spain, France, Germany, Luxembourg, and Iceland) in adults (age range: 20–45 years). Multivariable-adjusted pooled quantile regressions were employed to assess median differences (β coefficients) with 95% confidence ...