| Summary: | The Study involved twenty healthy adult white male rabbits (Lepus arcticus L.). the average weight (1500- 1600) Kg and aged from eight months to one year. The rabbits ware divided to four groups(G) each group contains five rabbits. G1 was treated with normal saline (1.5) ml orally as negative control group, G2 was treated with lead acetate (150) mg/kg as positive control group, G3 was treated with the aqueous extract of the Panax ginseng (400 ) mg/kg b.wt and G4 was treated with the aqueous extract of the Panax ginseng ( 400) mg/kg b.wt after 3 hours given them lead acetate (150 mg/kg b. wt/day) for peroid 30 days . study aimed to determine the protective role of Panax ginseng extract on the antioxidants glutathione GSH and oxidants malondialdehyde (MDA) in the blood serum of male rabbits for 30 days. The result of present study showed: increase (P<0.05) in mean levels of glutathione (GSH) in the (G3) and (G4) group compare with Second group (positive control G2). decrease (P<0.05) in mean levels of malondialdehyde (MDA) in group (G3) and (G4) compare with Second group (positive control G2).
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